乳腺癌髓系来源抑制细胞浸润与IL-6表达水平及患者预后的相关性研究  

Correlations of the infiltration of myeloid-derived suppressor cells with IL-6 expression and prognosis in patients with breast cancer

作　　者：陈洁英[1] 蒋蒙蒙[1] 于文文[1] 魏枫[1] 任秀宝[1] 于津浦[1,2] 

机构地区：[1]天津医科大学肿瘤医院免疫室,国家肿瘤临床医学研究中心,天津市肿瘤免疫与生物治疗重点实验室,天津市肿瘤防治重点实验室,天津市300060 [2]天津医科大学肿瘤医院肿瘤分子诊断中心,国家肿瘤临床医学研究中心,天津市肿瘤免疫与生物治疗重点实验室,天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2016年第6期228-234,共7页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81472473)资助~~

摘　　要：目的:探讨乳腺癌髓系来源抑制细胞(myeloid-derived suppressor cells,MDSCs)浸润与肿瘤组织原位白介素-6(interleukin-6,IL-6)表达及患者预后的相关性。方法:收集天津医科大学肿瘤医院2012年10月至2014年10月间经手术切除的113例女性乳腺癌石蜡组织切片、上海芯超生物科技有限公司提供的2001年1月至2004年8月经手术切除的女性乳腺癌患者组织芯片140例,免疫组织化学方法检测肿瘤源性IL-6表达水平和MDSCs浸润情况,分析MDSCs的浸润与IL-6表达的相关性,以及MDSCs浸润与临床病理指标及预后的相关性。结果:MDSCs浸润与肿瘤大小、淋巴结受累、病理分期、组织分级和患者预后相关,MDSCs浸润数与IL-6表达水平相关。结论:乳腺癌细胞分泌的IL-6可能是肿瘤局部MDSCs浸润与募集的原因之一,乳腺癌MDSCs浸润可作为患者预后不良的预测因素。Objective： To investigate the correlation of the infiltration of myeloid-derived suppressor cells（MDSC） with interleukin-6（IL-6） expression and prognosis in patients with breast cancer. Methods： Tumor tissue slices were obtained from patients with breast cancer who underwent surgery. The expression of IL-6 and the number of MDSCs were detected through immunohistochemistry analysis.The correlation of MDSC infiltration with IL-6 expression and prognosis in patients with breast cancer was also analyzed. Results： MDSC infiltration was correlated with the infiltration of lymph nodes, tumor volume, tumor stage, histology grade, and overall survival of the patients. MDSC infiltration was also significantly correlated with IL- 6 expression. Conclusion： IL- 6 secreted by breast cancer cells may induce local infiltration and aggregation of MDSCs. Increased number of MDSCs could be the negative prognostic factor of patients with breast cancer.

关 键 词：乳腺癌 髓系来源抑制细胞 白介素-6 预后 

分 类 号：R737.9[医药卫生—肿瘤]