Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌中的表达及意义  

Expression and significance of Survivin and Bcl-2in nasal aquamous cell carcinoma

作　　者：梁锦辉[1] 罗海林[1] 龙芳[1] 李莉[1] 黄河浪[1] 黄梅[1] 张翔[1] 毛谓东 

机构地区：[1]汉中市中心医院耳鼻咽喉头颈外科,陕西汉中723000 [2]汉中市中心医院病理科

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第7期529-531,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨凋亡相关蛋白Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌(SNSCC)中的表达及临床意义。方法:采用免疫组织化学Envision二步法检测35例SNSCC及20例正常下鼻甲黏膜标本中Survivin和Bcl-2的表达。结果:Survivin在SNSCC组织中的表达为88.6%,在正常下鼻甲黏膜组织无表达,二者差异有统计学意义(P<0.01)。Bcl-2在SNSCC组织中的表达为71.4%,明显高于正常下鼻甲黏膜组织的表达25%(P<0.01)。Survivin与Bcl-2的表达呈正相关(P<0.01)。肿瘤的分级程度越高,Survivin和Bcl-2的表达水平越低。结论:Survivin、Bcl-2与SNSCC的发生、发展有关,Survivin可能会成为SNSCC基因治疗的靶点。Objective：To investigate the expression and it＇s clinical significance of Survivin and Bcl-2in nasal squamous cell carcinoma（SNSCC）.Method：The immunohistochemical Envision two step method was used to measure the expression of Survivin and Bcl-2in 35 cases of SNSCC,20 cases of normal inferior concha tissues.Result：The expression of Survivin in SNSCC was 88.6%,significantly higher than the normal inferior turbinate mucosal tissue expression of 0%（P〈0.01）.The expression of Bcl-2in SNSCC was 71.4%,significantly higher than the normal inferior turbinate mucosal tissue expression of 25%（P〈0.01）.Expression of Bcl-2was significantly higher in SNSCC than in normal tissue.The expression of Survivin was positively correlated with Bcl-2expression（P〈0.01）.The higher the grade of tumor,the lower expressions of Survivin and Bcl-2.Conclusion：Survivin and Bcl-2may play an promoting role in the development and progression process of SNSCC.Survivin may become a target spot of SNSCC gene therapy.

关 键 词：鼻腔 鼻窦 癌 鳞状细胞 SURVIVIN BCL-2 

分 类 号：R739.62[医药卫生—肿瘤]