2638例细胞DNA定量分析法筛查宫颈癌的意义  

The significance of the DNA quantitative analysis in screening of 2 638 cervical cancer patients

作　　者：刘国生[1] 王晓亮[1] 郑建琼[1] 曾守逵 周维[1] 

机构地区：[1]湖北民族学院附属民大医院医学检验科,湖北恩施445000

出　　处：《分子诊断与治疗杂志》2016年第2期99-103,共5页Journal of Molecular Diagnostics and Therapy

基　　金：湖北省恩施州农业与社会发展科技指导性计划项目(恩州科业[2013]9号)

摘　　要：目的通过DNA定量分析法筛查恩施地区社区妇女宫颈病变的发病情况,明确其在筛查及预防宫颈癌变的作用。方法对2013年12月至2014年11月在湖北民族学院附属民大医院自愿免费参加宫颈疾病普查的恩施州社区妇女,采用宫颈刮片采集宫颈脱落细胞样本进行分析。结果2 638例普查者中,发现异倍体细胞和异倍体细胞峰以及细胞异常增生共131例,占4.97%,经病理确诊为宫颈上皮内瘤样病变(cervical intraepithelial neoplasias,CIN)45例,细胞DNA定量分析阳性患病率34.35%。结论采用细胞DNA定量分析法能及早发现宫颈癌前病变,通过妇女宫颈癌及癌前病变筛查可提高宫颈病变检出率。Objective To screen for the incidence of cervical lesions in women in Enshi by DNA quantitative cytology, and to investigateits effects in screening and preventing of cervical lesions. Methods DNA quantitative cytology and pathology were used in the medical examination of women who volunteered in the census of cervical disease in Affiliated Hospital of Hubei University for Nationalities from December, 2013 to November, 2014. Results A total of 131 cases of heteroploid cell, aneuploid peaks and abnormal proliferation were found, with an incidence of 4.97% in 2 638 cases. 45 cases of cervical intraepithelial neoplasias（CIN） were diagnosed by DNA quantitative cytology, with the positive prevalence rate of 34.35%.Conclusion DNA quantitative cytology is an effective way to detect CIN betimes, and cervical cancer and precancerous lesions screening may improve the detection rate of cervical lesions.

关 键 词：细胞DNA定量分析 筛查 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]