口腔鳞状细胞癌肿瘤标记物的研究  

Investigation on the tumor markers of oral squamous cell carcinoma

作　　者：邵婷如 赵萌[1] 吕晓智[1] 

机构地区：[1]南方医科大学南方医院口腔-头颈外科,广东广州510515

出　　处：《分子诊断与治疗杂志》2016年第2期123-129,共7页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81472536);广东省自然科学基金(S2011010003852);广东省科技计划(2012B031800139);广东省医学科研基金(A2012362);2013年南方医院新业务新技术课题(2013015)

摘　　要：口腔鳞状细胞癌（oral squamous cell carcinoma,OSCC）不仅危及患者的生命,还影响其美观和生存质量。虽然以手术、放疗和化疗为主的综合序列治疗方法不断完善,晚期OSCC的5年生存率只有40%~50%,但是早期患者的5年生存率高达85.4%。因此,OSCC的早期诊断对提高其疗效至关重要。研究证实,肿瘤标记物（tumor markers,TM）对于多种恶性肿瘤的早期诊断和监测非常有价值,但关于OSCC的TM研究,文献报道较少,如果能找出特异性的TM,将对OSCC患者的早期诊断,治疗和预后判断提供帮助。本文就此做一综述。Oral squamous cell carcinoma（OSCC） not only endangers patients＇ lives, but also effects their cosmetic appearances, and quality of lives. Despite improvements in therapeutic approaches such as comprehensive therapies with operation, radiotherapy, and chemotherapy, the 5-year overall survival rates for patients with late-stage tumorsare between 40% and 50%. However, for patients with early-stage tumors, the5-year overall survival rates rise to 85.4%. Accordingly, early detection of OSCC is sorely needed to improve patients＇ outcomes. It is confirmed that suitable tumor markers（TM） are essential for early diagnostic and monitoring of malignant tumors in early stages. However, there are few literature reported. In this paper,specific tumor markers which are helpful for early diagnosis, treatment and prognosis in patients with OSCC will be discussed.

关 键 词：口腔 鳞状细胞癌 肿瘤标记物 

分 类 号：R739.85[医药卫生—肿瘤]