Toll样受体4与结直肠癌的相关性  

The relationship of toll-like receptor 4 and colorectal cancer

作　　者：赵祥梅[1] 戴盛明[1] 

机构地区：[1]广西医科大学第四附属医院医学检验科柳州市肿瘤疾病与防治重点实验室,广西柳州545005

出　　处：《分子诊断与治疗杂志》2016年第2期130-134,共5页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81160269)

摘　　要：Toll样受体4(toll-like receptor 4,TLR4)在炎症诱发的结直肠癌(colorectal cancer,CRC)中的作用日益受到关注。活化的TLR4通过髓样分化因子88(myeloid differentiation factor 88,My D88)激活核转录因子-κB(nuclear factor-κB,NF-κB)产生大量炎症介质并募集炎症细胞形成肿瘤微环境,从而成为炎症与肿瘤的纽带贯穿于CRC发生、发展的整个过程中。本文着重对TLR4信号通路参与CRC的起始、进展、转移、遗传变异和表观遗传调控进行了讨论。尤其,文章中强调了TLR4在CRC发展和发病机制中的角色,并提出调节TLR4信号通路可能为CRC的治疗带来新的前景。The purpose of this article is to study the role that toll-like receptor 4（TLR4） plays in colitis associated colorecal cancer（CRC）. The activated TLR4 activates nuclear factor-κB（NF-κB） by myeloid differentiation factor 88（My D88）, which produces inflammatory mediators and recruits inflammatory cells to form the tumor microenvironment. TLR4 becomes a link between inflammation and cancer throughout the whole process of the occurrence and development of CRC. In this paper, a comprehensive review on the involvement of the TLR4 pathway in the initiation, progression, metastasis,inherited genetic variation, and epigenetic regulation of CRC will be discussed. In particular,the physiological role of TLR4 in the development and pathogenesis of CRC, and promising approaches for the therapy of CRC by TLR4 will be proposed.

关 键 词：TOLL样受体4 结直肠癌 发生 发展 

分 类 号：R735.34[医药卫生—肿瘤]