益生菌增效治疗幽门螺杆菌感染的疗效分析  

Efficacy analysis of probiotics-added treatment for helicobactor pylori infection

作　　者：尹玲苓[1] 

机构地区：[1]莱州市人民医院消化内科,261400

出　　处：《国际医药卫生导报》2016年第7期970-973,共4页International Medicine and Health Guidance News

摘　　要：目的探讨益生菌增效治疗幽门螺杆菌感染的临床疗效。方法收集我院2013年6月至2015年6月入院的400例幽门螺杆菌感染患者随机分为两组。对照组患者给予三联疗法治疗，实验组患者加用益生菌治疗，比较两组患者相关临床症状改善率、幽门螺杆菌清除率与不良反应。结果实验组慢性胃炎、胃溃疡与十二指肠溃疡患者临床症状改善率显著高于对照组（87．3％vs．65．32％，71．43％vs．38．71％，69．57％vs．42．22％），差异有统计学意义（P〈0．05）；实验组总体临床症状改善率显著高于对照组（81％vs．56％），差异有统计学意义（P〈0．01）。实验组慢性胃炎、胃溃疡与十二指肠溃疡患者幽门螺杆菌清除率显著高于对照组（65．87％vs．48，39％，50％vs．22．58％，45．65％vs．22．22％），差异有统计学意义（P〈0．05）；实验组总体幽门螺杆菌清除率显著高于对照组（59％vs．38．5％），差异有统计学意义（P〈0．01）。两组患者腹胀腹泻、皮肤红肿出疹、食欲减退与头昏乏力单独不良反应与总体不良反应发生率不存在统计学差异（P〉0．05）。结论益生菌增效治疗幽门螺杆菌感染的临床疗效显著，具有借鉴性。Objective To explore the clinical efficacy of probiotics-added treatment for helicobactor pylori infection. Methods 400 cases ofhelicobactor pylori infection admitted in our hospital from June 2013 to June 2015 were collected and randomly divided into two groups. Control group was treated with triple therapy; and experimental group was treated with probiotics on the basis of triple therapy. The improvement rate of corresponding clinical symptoms, the clearance rate of helicobactor pylori and adverse reactions of two groups were compared. Results The improvement rate of clinical symptoms of chronic gastritis patients, gastric ulcer patients, duodenal ulcer patients in experimental group were significantly higher than those in control group （87.3% vs.65.32%, 71.43% vs.38.71%, 69.57% vs.42.22%）, with statistically significant differences （P〈0.05）. The overall improvement rate of clinical symptoms in experimental group was significantly higher than that in control group （81% vs.56%）, with statistically significant difference （P〈0.01）. The clearance rate of helicobactor pylori of chronic gastritis patients, gastric ulcer patients, duodenal ulcer patients in experimental group were significantly higher than those in control group （65.87% vs.48.39%, 50% vs.22.58%, 45.65% vs.22.22%）, with statistically significant differences （P〈0.05）. The overall clearance rate of helicobactor pylori in experimental group was significantly higher than that in control group （59% vs.38.5%）, with statistically significant difference （P〈0.01）. There were no statistically significant differences in the incidences of abdominal distention and diarrhea, red swelling skin with rash, anorexia, dizziness and asthenia, the overall adverse reaction rate between two groups （P〉0.05）. Conclusion The probiotics-added treatment for helicobactor pylori infection has significant clinical efficacy, of reference in clinical practice.

关 键 词：益生菌 幽门螺杆菌 清除率 不良反应 

分 类 号：R573[医药卫生—消化系统]