卵圆孔未闭相关隐源性脑卒中影像学特征分析  

Brain magnetic resonance imaging findings in cryptogenic stroke patients with patent foramen ovale

作　　者：邹兴菊[1] 李进[1] 黄建[1] 王静[1] 朱浩[1] 黄冬[1] 刘之荣[1] 

机构地区：[1]第四军医大学西京医院神经内科,陕西西安710032

出　　处：《中华神经外科疾病研究杂志》2016年第2期109-112,共4页Chinese Journal of Neurosurgical Disease Research

基　　金：国家自然科学基金资助项目(81070950)

摘　　要：目的探讨卵圆孔未闭(PFO)与隐源性脑卒中(CS)间的关联性,及伴有卵圆孔未闭的隐源性脑卒中患者头颅磁共振-弥散加权成像(MRI-DWI)的特征。方法回顾性分析西京医院神经内科139例隐源性脑卒中患者的MRI-DWI特征,具体分组为:CS-PFO(+)组(n=91,65.5%)和CSPFO(-)组(n=48,34.5%)。结果合并PFO的CS患者所占比例明显高于无PFO患者,而且弥散加权成像(DWI)显示与CS-PFO(-)组相比CS-PFO(+)组梗死灶主要累及皮层及皮质下≥15 mm的单发梗死灶,P<0.05,差异有统计学意义;另外两组梗死灶在血管分布区域上均以大脑中动脉(MCA)所占比例最多,但均无统计学意义。结论卵圆孔未闭可能是隐源性脑卒中患者的一个重要致病因素,CS-PFO(+)患者梗死灶分布以累及皮层-皮质下≥15 mm为主。Objective The association between patent foramen ovale（ PFO） and cryptogenic stroke（ CS） and the characteristics of infarction on diffusion-weighted imaging（ DWI） aid in PFO are discussed.Methods The clinical data of 139 cases with cryptogenic stroke,who admitted to Department of Neurology,Xijing Hospital,were analyzed retrospectively.All the subjects were divided into two groups： group with PFO（ n =91,65.5%） and group without PFO（ n = 48,34.5%）.Diffusion-weighted imaging of brain Magnetic Resonance Imaging（ MRI） was performed by two radiologists blinded to clinical data.Results The proportion of cryptogenic stroke with PFO was larger than that of the patients without PFO.A single involvement to the subcortical lesions larger than 15 mm was more likely to be PFO-associated（ P〈0.05）.In addition,the majority of infarcts involved in middle cerebral artery in both groups.Conclusion The different diffusion-weighted imaging characteristics between group with PFO and group without PFO suggest that PFO is related to cryptogenic stroke.A single and larger than 15 mm subcortical infarct seems to favor PFO as a stroke etiology.

关 键 词：卵圆孔未闭 隐源性脑卒中 梗死灶 弥散加权成像 

分 类 号：R743.3[医药卫生—神经病学与精神病学]