腹腔镜胃癌根治术的疗效及对调节性T细胞的影响  

Curative effect of laparoscopic radical gastrectomy for gastric cancer and its effect on regulatory T cells

作　　者：杨少辉[1] 赵逸斌[1] 

机构地区：[1]宁波市医疗中心李惠利医院普外科,浙江宁波315000

出　　处：《中国现代医生》2016年第8期15-17,21,共4页China Modern Doctor

基　　金：浙江省宁波市科技计划项目(2015A610223)

摘　　要：目的研究腹腔镜胃癌根治术的手术效果及对调节性T细胞的影响。方法将2012年6月~2014年9月住院治疗的80例行胃癌根治术患者纳入本研究,随机分为腹腔镜组、开腹手术组(对照组),每组各40例,比较两组反映术后恢复情况的各项指标及调节性T细胞术前术后的变化情况以及术后并发症情况。结果腹腔镜组的CD4^+、CD4^+/CD8+水平术后3 d、术后7 d较术后1 d逐渐升高,术后7 d接近术前水平,而对照组CD4^+、CD4^+/CD8^+术后3 d、术后7 d与术后1 d基本一致,未见明显变化,且分别显著低于腹腔镜组(P<0.05)。腹腔镜组术中失血量较少,显著少于对照组,腹腔镜组患者术后下床活动时间早,肛门排气时间快,术后疼痛轻,住院时间短(P<0.05)。腹腔镜组的并发症显著少于对照组(5.0%vs 30.0%,P<0.05)。结论腹腔镜胃癌根治术手术效果确切,患者术后恢复快、并发症少,且通过对患者调节性T细胞的检测,证实该手术方法对患者的机体的免疫功能影响较小,值得推广和应用。Objective To study the effect of laparoscopic radical gastrectomy for gastric cancer and the effect of T cells on the regulation of gastric cancer. Methods A total of 80 patients with gastric cancer radical surgery from June 2012 to Sepember 2014 were randomly divided into laparoscopic group and control group, each with 40 cases in each, reflect postoperative recovery of various measures and regulatory T cells in preoperative postoperative changes and postoperative complications were compared between the two groups. Results Laparoscopic group of CD4^＋, CD4^＋/CD8^＋levels after3 days, 7 days after operation were increased gradually compared with the 1 d after operation. After 7 days to preoperative levels, CD4^＋, CD4^＋/CD8^＋postoperative 3 days, 7 days after operation and postoperative 1 day of control group were basically the same and the control group were significantly lower than that in the laparoscopic group（P〈0.05）. In the laparoscopic group, the blood loss quantity was less, significantly less than that of the control group, patients of laparoscopic group with earloer out of bed activity time, quicker anal exhaust time, litter postoperative pain, shorter hospital ization time（P〈0.05）. The complications in the laparoscopic group was significantly less than the control group（5.0% vs30.0%, P〈0.05）. Conclusion Laparoscopic surgery for gastric cancer radical surgery is effective, postoperative recovery fast, with less complications and by regulating in patients with T cell detection confirmed the surgical method for patients with the body＇s immune function effect is smaller, worthy of promotion and application.

关 键 词：腹腔镜胃癌根治术 调节性T细胞 并发症 免疫功能 

分 类 号：R735.2[医药卫生—肿瘤]