雷贝拉唑、克拉霉素、阿莫西林、胶体铋剂四联治疗幽门螺杆菌感染慢性胃炎的疗效探讨  

Efficacy of Rabeprazole, Clarithromycin, Amoxicillin and Colloidal Bismuth Quadruple Therapy in the Treatment of Chronic Gastritis Due to Helicobacter Pylori Infection

作　　者：李小伟 李克泉 徐敏 

机构地区：[1]山东省青岛市胶州中心医院,山东青岛266300

出　　处：《中外医疗》2016年第1期49-51,共3页China & Foreign Medical Treatment

摘　　要：目的探讨雷贝拉唑、克拉霉素、阿莫西林联合胶体铋剂治疗幽门螺杆菌感染的慢性胃炎患者的疗效。方法整群选取2013年1月—2014年12月期间该院消化内科门诊或住院患者中明确诊断为幽门螺杆菌阳性的慢性胃炎患者185例,将其随机分成治疗组(n=64)、观察组(n=59)和对照组(n=62),治疗组给予雷贝拉唑、克拉霉素、阿莫西林和胶体铋剂四联治疗,观察组给予雷贝拉唑、克拉霉素、甲硝唑、胶体铋剂四联治疗,对照组给予雷贝拉唑、克林霉素、胶体铋剂三联治疗,比较3组患者的疗效。结果治疗组、观察组、对照组幽门螺杆菌根除率分别为92.19%(59/64)、84.75%(50/59)、76.27%(45/59),3组比较差异有统计学意义(P<0.05);治疗组、观察组、对照组消化道症状缓解率分别为89.06%(57/64)、71.19%(42/59)、为62.90%(39/62),差异有统计学意义(P<0.05);治疗组、观察组、对照组溃疡愈合率分别为90.63%(58/64)、89.83%(53/59)、80.65%(50/62),差异有统计学意义(P<0.05)。结论雷贝拉唑、克拉霉素、阿莫西林联合胶体铋剂治疗幽门螺杆菌感染的慢性胃炎疗效较佳,幽门螺杆菌的根除率、消化道症状缓解率和溃疡愈合率均较高,值得临床推广应用。Objective To discuss the effect of rabeprazole, clarithromycin, amoxicillin and colloidal bismuth in the treatment of chronic gastritis due to Helicobacter pylori infection. Methods 185 cases confirmedly diagnosed with Helicobacter pylori-positive chronic gastritis, including the patients admitted in Department of Gastroenterology Outpatient or hospitalized in our hospital from January 2013 to December 2014 were selected and randomly divided into the treatment group（n =64）, the observation group（n = 59） and the control group（n=62）. The treatment group were given rabeprazole, clarithromycin,amoxicillin and colloidal bismuth quadruple therapy, the observation group were given rabeprazole, clarithromycin, metronidazole, colloidal bismuth quadruple therapy; the control group were given rabeprazole, clindamycin, colloidal bismuth triple therapy treatment. And the efficacy of the three groups was compared. Results The eradication rate of Helicobacter pylori was 92.19%（59/64）, 84.75%（50/59） and 76.27%（45/59）, respectively in the treatment group, observation group and control group with statistically significant difference between the three groups（P〈 0.05）. The gastrointestinal symptoms remission rate was 89.06%（57/64）, 71.19%（42/59）, and 62.90%（39/62）, respectively in the treatment group, observation group and control group with statistically significant difference between the three groups（P〈 0.05）. The ulcer healing rate was 90.63%（58/64）,89.83%（53/59） and 80.65%（50/62）, respectively in the treatment group, observation group and control group with statistically significant difference between the three groups（P〈 0.05）. Conclusion For the treatment of chronic gastritis due to Helicobacter pylori infection, rabeprazole, clarithromycin, amoxicillin and colloidal bismuth have better effect with higher eradication rate of Helicobacter pylori, gastrointestinal symptoms remission rate and ulcer healing rate, so the therapy is worthy of clinical application and p

关 键 词：幽门螺杆菌 慢性胃炎 克拉霉素 阿莫西林 

分 类 号：R573.1[医药卫生—消化系统]