肺积散对顺铂化疗肺癌小鼠造血及免疫功能的影响  

Effects of Feiji San(肺积散) on Hematopoiesis and Immunologic Function of Mice with Lung Cancer Treated with Chemotherapy

作　　者：吴敏[1] 徐小华[2] 

机构地区：[1]浙江省杭州市中医院,浙江杭州310007 [2]浙江省衢州市人民医院,浙江衢州324000

出　　处：《中国中医药科技》2016年第2期157-158,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：国家自然基金项目(81202918)

摘　　要：目的:观察肺积散对顺铂化疗肺癌小鼠造血功能及免疫功能的影响。方法:建立荷瘤小鼠模型,实验分为正常组、模型组、肺积散组、顺铂组及顺铂与肺积散联合组,每组8只。分组给药3 W,检测各组小鼠外周血细胞的变化及流式细胞仪检测CD_3^+、CD_4^+、CD_8^+的数量并计算CD_4^+/CD_8^+比值。结果:肺积散对肺癌小鼠外周血白细胞、红细胞、血红蛋白、血小板均无明显影响,与顺铂联合应用组外周血白细胞和血小板较单纯顺铂组明显升高。肺积散对T淋巴细胞亚群没有明显影响,与顺铂联合应用组CD_4^+明显升高,CD_8^+明显降低,CD_4^+/CD_8^+比值明显升高。结论:肺积散可以明显改善顺铂化疗小鼠造血功能抑制及免疫功能低下。Objective： To observe the effects of Feiji San on hematopoiesig and immunologic function of mice with lung cancer treated with chemotherapy. Methods： Mice bearing lung cancer were prepared, experiment was divided into five groups, normal, model, Feiji San, cisplatin and cisplatin with Feiji San groups, 8 mice in each group. Each group was given the corresponding medicine for 3 weeks, the peripheral blood ceils and T lymphocyte subsets were determined. Results： Feiji San had no influence on peripheral blood ceils of mice with lung cancer, but Feiji San combining with cisplatin could obviously raise peripheral blood leucocyte and platelet count . Feiji San had no influence on T lymphocyte subsets of mice with lung cancer, Feiji San combining with cisplatin could obviously raise CD4＋ level and reduce CDs level, recover the balance of CD4＋/CDs. Conclusion： Feiji San can improve the inhibition of hematopoietic function in mice with lung cancer treated with chemotherapy, and enhance the immunity

关 键 词：肺肿瘤 化疗 肺积散 血细胞计数 T淋巴细胞 小鼠 

分 类 号：R734.2[医药卫生—肿瘤]