长期住院男性精神分裂症患者伴发代谢综合征危险因素研究  

Study on risk factors of metabolic syndrome in long term hospitalized male patients with schizophrenia

作　　者：唐开宏[1] 闫妍[2] 严琦[1] 宋红兵[1] 

机构地区：[1]江苏省南通市第四人民医院,江苏南通226002 [2]上海市民政第一精神卫生中心

出　　处：《中国民康医学》2016年第6期1-3,40,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨长期住院男性精神分裂症患者代谢综合征(MS)的危险因素。方法:选取住院2年以上的男性精神分裂症患者173例,收集患者的年龄、住院时间、服药时间、体质量、体质量指数(BMI)、腰围、臀围、血压、空腹血糖、胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯。以是否发生MS分为非MS组(98例)和MS组(75例)。分析两组患者间代谢相关因素的差异,并进行Logistic回归分析。结果:MS组患者的患病率为43.35%,腰围、甘油三酯(TG)、空腹血糖、收缩压、舒张压明显高于非MS组;高密度脂蛋白(HDL-C)明显低于非MS组(P<0.01);年龄、服药时间、臀围、体质量及体质量指数(BMI)均高于非MS组(P<0.05或0.01)。结论:长期住院男性精神分裂症患者MS的患病率高于普通人群,MS患者具有更高的年龄、服药时间、体质量、体质量指数(BMI)、腰围、臀围、血压、空腹血糖及甘油三酯水平,其高密度脂蛋白水平偏低。发生MS的独立危险因素为血糖偏高、BMI增大及用药时间较长。Objective To explore the risk factors of metabolic syndrome （MS） in long term hospitalized male patients withschizophrenia. Methods： 173 schizophrenic male patients hospitalized for more than 2 years were selected to obtain their clinical information, which included age, hospitalization time, duration of antipsychotics, body weight, body mass index （BMI）, waist circumference, hip circumference, blood pressure, fasting blood glucose, and levels of total cholesterol, high density lipoprotein （HDL-C）,low density lipoprotein and triglyceride （TG）. All patients were divided into MS group and non-MS group according to the diagnosticcriteria of MS. All the variables associated with MS were compared between the two groups and then were analyzed by using logistic regression analysis. Results： The prevalence of MS in MS group was 43. 35%, and waist circumference, the level of TG, fasting plasmaglucose, systolic pressure, diastolic pressure in MS group were significantly higher than those in non-MS group （P〈0. 01）. The levelof HDL-C in MS group was significantly lower than that in non-MS group （P〈0. 01）, while age, duration of antipsychotics, hip circumference, body weight and BMI in MS group were significantly higher than those in the non-MS group （P〈0. 05 or 0. 01）. Conclusions： The prevalence of MS in the long term hospitalized male patients with schizophrenia is higher than that of the general population.These patients with MS tend to have advanced age, long duration of anti-psychotics, and high body weight, BMI, waist circumference,hip circumference, blood pressure, and levels of fasting blood glucose and TG, but low level of HDL-C. The independent risk factorsof MS in the schizophrenic patients consist of high blood glucose, high BMI and long duration of anti-psychotics.

关 键 词：精神分裂症 长期住院 代谢综合征 危险因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]