小剂量喹硫平对文拉法辛治疗抑郁症患者的增效作用  

Synergistic effects of small dose Quetiapine on depression treated with Venlafaxine

作　　者：杨红梅[1] 王兆军[2] 梁家騋[1] 孙克峰[1] 杨猛[1] 

机构地区：[1]济南市精神卫生中心,山东济南250032 [2]济南市第四人民医院

出　　处：《中国民康医学》2016年第6期15-16,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨小剂量喹硫平对文拉法辛治疗抑郁症患者的增效作用和安全性。方法:将60例抑郁症患者随机分为研究组和对照组,每组各30例。研究组患者给予文拉法辛合并喹硫平治疗,对照组患者单用文拉法辛治疗,研究疗程为8周。采用汉密尔顿抑郁量表(HAMD)评定两组患者的临床疗效。结果:治疗后,两组患者的HAMD评分均显著下降(P<0.05或P<0.01)。研究组患者的HAMD减分更明显,两组患者比较,差异显著(P均<0.05)。研究组患者起效更快,临床显效率高于对照组(P<0.05)。结论:小剂量喹硫平对文拉法辛治疗抑郁症患者具有明显增效作用,不良反应无增,疗效有加,安全性好,是一种不错的增效策略。Objective To explore synergistic effects and safety of small dose Quetiapine on depression treated with Venlafaxine. Methods： 60 patients with depression were randomly divided into two groups （30 cases in each group）： the study group was givenVenlafaxine combined with Quetiapine and the control group was treated with Venlafaxine only. The treatment lasted for 8 weeks. Theefficacy was assessed with Hamilton depression scale （HAMD）, and the adverse reactions were evaluated by treatment emergent symptom scale （TESS）. Results： After the treatment, the HAMD scores of the two groups were significantly reduced （P〈0. 05 or P〈0. 01）. The change of the HAMD score of study group was more significant, and the difference between the two groups was significant（P〈0. 05）. The study group had a rapid response and the clinical efficiency was higher than that of control group （x2 = 2. 22; P〈0. 05）. Conclusions： The small dose Quetiapine has an obvious synergistic effect on depression treated with Venlafaxine without increased side effects. It has a good efficacy and high safety, and is a kind of good synergic strategy.

关 键 词：抑郁症 文拉法辛 喹硫平 

分 类 号：R749.41[医药卫生—神经病学与精神病学]