丹参酮ⅡA磺酸钠对肝门阻断术后血流动力学及流变学影响  

Effect of Sulfotanshinone Sodium Injection on Hemodynamics and Hemorheology in Patients with Hepatic Portal Occlusion

作　　者：刘恩宇[1] 王奔[1] 赵传宗[1] 李斌[1] 陈雨信[1] 

机构地区：[1]山东大学齐鲁医院肝胆外科,山东济南250012

出　　处：《现代生物医学进展》2016年第10期1842-1845,共4页Progress in Modern Biomedicine

基　　金：山东省自然科学基金项目(ZR2013HQ051)

摘　　要：目的:探讨丹参酮ⅡA磺酸钠注射液对行肝门阻断术患者血流动力学及血液流变学影响。方法:选取我院肝胆外科收治的原发性肝癌患者92例,随机数字表达法分为2组,其中对照组46例,全麻行肝癌根治术治疗;实验组46例,在手术前7 d予以丹参酮ⅡA磺酸钠注射液,80 mg注入150 m L 0.9%氯化钠注射液中,日一次静滴,连续治疗7 d。分别观察两组患者肝门阻断前及阻断后1 min,5 min,10 min,20 min和解除阻断后30 min血流动力学及血液流变学。结果:1实验组患者肝门阻断后10 min和阻断20 min两个时间段的心率(Heart rate,HR)明显低于对照组同时间段HR,平均动脉压(Mean arterial pressure,MAP)、心排出量(Cardiac output,CO)、左室做功指数(The left ventricular work index,LCWI)明显高于对照组同时间段,差异有统计学意义(P<0.05)。2实验组患者肝门阻断后10 min和阻断20 min两个时间段的全血高切粘度、全血低切粘度、血浆比粘度和纤维蛋白定量明显低于对照组同时间段,差异有统计学意义(P<0.05)。结论:丹参酮ⅡA磺酸钠注射液能够明显改善肝门阻断术引起的血流动力学及血液流变学各项指标,从而保证原发性肝癌手术过程中肝脏的供血量,防止血液凝聚导致的血栓形成。Objective： To investigate the effect of Sulfotanshinone Sodium injection on hemodynamics and hemorheology in patients with hepatic portal occlusion. Methods： Total of 92 cases with primary hepatocellular carcinoma（HCC） was randomly divided into two groups, 46 cases in control group and 46 cases in experimental group. The patients in control group were treated with radical hepatectomy, and the patients in experimental group were treated with Sulfotanshinone Sodium injection, 80 mg dissolved into 150 m L0.9 % sodium chloride injection, once a day by intravenous drip, continuous treatment of 7 days, then received the surgery. The change of hemodynamics and hemorheology was observed before occlusion, and 1 min, 5 min, 10 min, 20 min after occlusion and 30 min after the occlusion was removed. Results： HR in the experimental group in 10 min and 20 min after hepatic portal occlusion was significantly lower than that of the control group at the same time, but the level of MAP, CO and LCWI was significantly higher in experimental group than that of control group at the same time, and the difference was statistically significant（P〈0.05）. The whole blood high shear viscosity, whole blood low shear viscosity, plasma specific viscosity and fibrinogen quantitative was significantly lower in experimental group in 10 min and 20 min after hepatic portal occlusion than that of the control group at the same time, and the difference was statistically significant（P〈0.05）. Conclusions： Sulfotanshinone Sodium Injection can obviously improve the hemodynamics and hemorheology indexes caused by hepatic portal occlusion, so as to ensure the blood supply to the liver during hepatic surgery and prevent the thrombus formation.

关 键 词：丹参酮ⅡA磺酸钠 肝门阻断术 血流动力学 血液流变学 

分 类 号：R735.7[医药卫生—肿瘤] R285.6[医药卫生—临床医学]