胃黏膜肠上皮化生的危险因素  

Risk factors for gastric intestinal metaplasia

作　　者：柯丽[1] 张迪[1] 时永全[1] 

机构地区：[1]第四军医大学西京医院消化内科,陕西省西安市710032

出　　处：《世界华人消化杂志》2016年第9期1307-1314,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81270445;81370484;81470805~~

摘　　要：胃黏膜肠上皮化生是胃癌常见的癌前病变.由于胃癌尤其是晚期胃癌总体治疗效果不佳,防治胃癌的关键应是降低发生率和提高早期诊断率.因此,阐明胃癌及其癌前病变的危险因素对于胃癌的一级预防具有重要意义.大量研究发现,胃黏膜肠上皮化生的发生与幽门螺杆菌感染、年龄、性别、胃癌家族史、吸烟、高盐饮食、胆汁酸反流等密切相关.本文仅就上述危险因素进行述评.Gastric intestinal metaplasia is the most common precancerous lesion of gastric cancer. Due to the unsatisfying treatment efficacy for gastric cancer especially advanced gastric cancer, the key steps of prevention and treatment of gastric cancer are lowering the incidence and improving the early diagnosis. Therefore, it is very important to clarify the risk factors associated with gastric cancer and its precancerous lesion for firstline prevention of gastric cancer. Accumulated evidence indicates that the development of gastric intestinal metaplasia is closely related to Helicobacter pylori infection, age, sex, family history of gastric cancer, smoking, high salt diet, bile acid reflux and so on. This review mainly focuses these factors associated with gastric intestinal metaplasia.

关 键 词：胃黏膜肠上皮化生 危险因素 胃癌 

分 类 号：R573[医药卫生—消化系统] R735.2[医药卫生—内科学]