奥拉西坦治疗血管性痴呆的临床疗效及对外周血IL-6水平的影响  

Clinical Efficacy of Oxiracetam for Vascular Dementia （VD） and Its Effect on Peripheral Blood IL-6 Levels in VD Patients

作　　者：倪妍妍 曹仕健[2] 唐发霞[3] 

机构地区：[1] 合肥市第一人民医院西区内一科,合肥市230031 [2] 安徽省中医院22病区,合肥市230031 [3] 合肥市第一人民医院西区神经内科,合肥市230031

出　　处：《医学分子生物学杂志》2016年第2期100-103,共4页Journal of Medical Molecular Biology

摘　　要：目的：评估奥拉西坦治疗对血管性痴呆的临床疗效及其对患者外周血IL-6水平的影响。方法纳入2013年6月～2015年6月我院收治的血管性痴呆患者120例，并随机分为治疗组（60例）和对照组（60例）。同时将同期我院体检正常的健康者60例为正常组。治疗组采用奥拉西坦进行治疗，对照组采用尼莫地平治疗。分析两组患者的临床疗效及治疗前后MMSE评分和外周血IL-6水平的变化，并分析其相关性。结果治疗组总有效率为90.0％，明显高于对照组（72％）（ P＜0.05）。两组患者治疗后MMSE评分均较治疗前明显改善（P＜0.05），而且治疗组MMSE评分改善程度明显高于对照组（P＜0.05）。两组患者治疗前外周血IL-6水平均明显高于正常组，治疗后两组患者外周血IL-6水平均较治疗前明显降低（ P＜0.05），而且，治疗组治疗后外周血IL-6水平明显低于对照组治疗后（P＜0.05）。相关性分析显示MMSE评分与外周血IL-6的水平呈负相关。结论奥拉西坦可能通过减轻炎性反应来改善血管性痴呆患者的认知功能，疗效显著，值得临床上进一步研究应用。Objective To evaluate the clinical efficacy of oxiracetam in the treatment of vascu-lar dementia and the effect of oxiracetam on peripheral blood IL-6 levels.Methods One hundred and twenty patients with vascular dementia were enrolled in the study from June 2013 to June 2015 at our hospital.They were randomly divided into two groups： treatment group （60 cases） and con-trol group （60 cases） .Patients in treatment group were treated with oxiracetam, and those in con-trol group with nimodipine.Sixty healthy people were enrolled in normal group.Clinical efficacy, the MMSE score and the levels of IL-6 were observed in the groups.The association between the MMSE score and the levels of IL-6 was analyzed.Results The overall effective rate was 90.0 %in treat-ment group, which was significantly higher than that in control group （72 %） （P〈0.05） .The MMSE score was significantly improved after treatment in both treatment and control groups, with the form group having better results （ P〈0.05 ） .The level of IL-6 was significantly reduced after treatment in both groups （ P〈0.05 ） .Furthermore, it was significantly lower in treatment group than in control group （ P〈0.05 ） .Correlation analysis showed that the IL-6 levels were negatively＆amp;nbsp;associated with MMSE score.Conclusion Oxiracetam may improve cognitive function by reducing inflammatory reaction and it is effective for the treatment of vascular disease.

关 键 词：奥拉西坦 血管性痴呆 白介素-6 

分 类 号：R745[医药卫生—神经病学与精神病学]