血清胱抑素C水平与认知功能损害的相关性研究  

Correlation between serum cystatin-C levels and cognitive impairment

作　　者：赵宇[1] 吕英慧[1] 张杰[1] 康晓新[1] 尹璐 韦艳红[1] 杨莉莉[1] 

机构地区：[1]齐齐哈尔医学院附属第三医院老年科,161000

出　　处：《中华老年医学杂志》2016年第4期352-354,共3页Chinese Journal of Geriatrics

基　　金：基金资助：黑龙江省教育厅科学技术研究项目资助（12541916）

摘　　要：目的探讨血清胱抑素C（Cys—c）水平与认知功能损害的相关性。方法前瞻性研究选择2013—2015年于齐齐哈尔医学院附属第三医院就诊的患者273例，分为认知功能损害组与对照组，检测血清胱抑素C水平、认知功能评分，调整可能的影响因素，分析Cysc水平与认知功能损害的关系。结果不同胱抑素c水平组中年龄、高血压、糖尿病、吸烟、饮酒、血脂异常、肌酐结果异常情况分布比较差异有统计学意义（P〈0．05或P〈0．01）；认知功能损害组Cys—C水平（0．727±0．082）mg／L与对照组（0．514±0．045）mg／L比较差异有统计学意义（t=23．68，P〈0．01）。认知功能损害组CysC水平与简明精神状态量表（MMSE）得分（r=0．318）、蒙特利尔认知评估量表（MOCA）得分（r=-0．572）均呈负相关（P〈0．05），随着Cys—C水平的升高，认知功能损害患病的发生率升高（x2=13．12，P〈0．01）；多因素Logistic回归分析结果显示，高Cys—C水平（OR=3．298，95％CI：1．417～7．675）、糖尿病史（OR=7．971，95％CI：3．036～31．562）、文化程度（OR=2．237，95％CI：1.022～4．896）、吸烟（OR=5．692，95％CI：1．060～2．614）、饮酒史（OR=1．227，95％CI：0．083～1．228，P=0．03）、血脂异常（OR=2．267，95％CI：1．1774-4．366）是导致认知功能损害的独立危险因素。结论高Cys—C水平与认知功能损害发生风险密切相关。Objective To investigate the correlation between serum cystatin C （Cys-C） levels and cognitive impairment. Methods A perspective study involving 273 patients in our hospital was performed from 2013 to 2015. They were divided into the cognitive impairment group and the control group. Cys-C measurement results and cognitive impairment assessment scores were collected. Possible influence factors were adjusted, and the correlation between Cys-C levels and mild cognitive impairment was analyzed. Results The distribution of age,hypertension, diabetes mellitus, smoking, drinking, dyslipidemia,and creatinine showed significant differences between the groups at different Cys-C levels （all P〈0.05）. There was a significant difference in the Cys-C level between the cognitive impairment group and the control group [（0. 727 ±0. 082） mg/L vs. （0.514±0.045）mg/L,t=23.68,P〈0.01]. The Cys C level was negatively correlated with the scores of mini-mental state examination （MMSE） and Montreal cognitive assessment （MOCA） in the cognitive impairment group （r=- 0. 318 and -0. 572,P〈0.05）. The incidence of cognitive impairment was elevated with increasing Cys-C levels （x2= 13.12 ,P〈0.01 ）. Logistic regression analysis showed that high levels of Cys-C （OR= 3. 298, 95% CI：1. 417-7. 675 ,P=0. 001）,history of diabetes mellitus （OR= 7. 971,95% CI：3. 036-31. 562,P =0.03）,education level （OR= 2. 237, 95% CI ：1.022-4.896,）,smoking （OR= 5. 692, 95% CI： 1. 060 2. 614） ,drinking （OR=1. 227,95% CI：0. 083-1. 228）,and dyslipidemia （OR=2. 267,95% CI： 1. 177-4. 366） are independent risk factors for cognitive impairment. Conclusions High serum cystatin C levels are closely correlated with the risk of cognitive impairment occurrence.

关 键 词：半胱氨酸蛋白酶抑制剂 认知障碍 

分 类 号：R749.16[医药卫生—神经病学与精神病学]