血清学肿瘤标志物与胰腺癌诊断及分期的关系  

Correlation between serum tumor markers and the diagnosis and staging of pancreatic cancer

作　　者：方恒忠[1] 陈炯[1] 赵金钱[1] 徐宏[1] 朱兴兴 

机构地区：[1]安徽医科大学附属省立医院普外科,合肥230001

出　　处：《国际外科学杂志》2016年第3期171-173,共3页International Journal of Surgery

基　　金：安徽省科技攻关项目（1401045020）;安徽省年度重点科技项目（1301043013）

摘　　要：目的探索血清学肿瘤标志物CA19-9、CEA及CA50与胰腺癌的早期诊断及分期的关系。方法通过收集分析安徽医科大学附属省立医院普外科2013年1月-2015年10月收治入院的51例胰腺癌患者、10例胰腺良性肿瘤患者、12例慢性胰腺炎患者血清中CA19．9、CEA及CA50的测量值，比较它们在不同分期的胰腺癌及其他胰腺疾病中血清含量的不同。结果CA19—9在不同分期胰腺癌及其他胰腺疾病中表达差异有统计学意义（P〈0．05）。CEA及CA50在胰腺癌与胰腺其他疾病中表达差异具有统计学意义（P〈0．05）。但CEA在Ⅰ期与Ⅱ期、Ⅰ期与Ⅲ期、Ⅱ期与Ⅲ期患者血清中的表达差异无统计学意义（P〉0．05）。CA50在胰腺癌Ⅰ期与Ⅲ期、Ⅱ期和IV期中表达差异无统计学意义（P〉0．05）。CA19—9诊断胰腺癌的阳性率高于CEA及CA50，CA19-9、CEA及CA50三者同时检测诊断胰腺癌的阳性率最高。结论CA19—9、CEA及CA50在血清中的表达水平对于胰腺癌的早期诊断有一定的相关性，在胰腺癌分期中CA19-9的诊断价值最高。Objective Resarech on the correlation between serum tumor markers CA19-9, CEA, CA50 and the early diagnosis and staging of pancreatic cancer. Methods To compare the serum levels of the CA19-9, CEA, CA50 in 51 patients with pancreatic cancer, 10 benign tumor patients and 12 chronic pancreatitis patients admitted to the Department of general surgery, Anhui Provincial Hospital from January 2013 to October 2015. Results CA19-9 expression in different stages of pancreatic cancer and other pancreatic diseases were statistically significant （ P 〈 0.05 ）. The difference of CEA and CA50 expression in pancreatic cancer and other pancreatic diseases was statistically significant （ P 〈 0.05 ）. But the CEA in stageⅠ and stage Ⅱ , stage Ⅰ and stage Ⅲ, stage Ⅱ and stage Ⅲ patients with clear expression of the difference was not statistically significant （ P 〉 0. 05 ）. The was no signifi- cant difference in the expression of CA50 in pancreatic cancer stage Ⅰ and stage Ⅱ , Ⅲ and Ⅳ （ P 〉 0.05 ）. The positive rate of CA19-9 in the diagnosis of pancreatic cancer was higher than that of CEA and CA50. The positive rate of CA19-9, CEA, CA50 and were the highest in the diagnosis of pancreatic cancer. Conclusions The expres- sion levels of CA19-9, CEA and CA50 in serum have a certain relevance to the early diagnosis of pancreatic cancer, and the value of CA19-9 is the highest in the stage of pancreatic cancer.

关 键 词：胰腺肿瘤 诊断 肿瘤分期 血清 肿瘤标记 

分 类 号：R737.9[医药卫生—肿瘤]