Lingo-1在中枢神经系统损伤疾病中的应用  

Lingo-1 as a new therapeutic target for central nervous system injury

作　　者：索磊[1] 杨印祥[1] 汤文燕 栾佐[1] 

机构地区：[1]解放军海军总医院儿科,北京100048

出　　处：《中华神经医学杂志》2016年第4期421-424,共4页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金，National Natural Science Foundation of China

摘　　要：Lingo-1在神经元轴突再生、成髓鞘细胞分化及髓鞘形成等信号通路中发挥了重要的负调控作用。本文围绕Lingo-1的结构、分布、生物学特性及其在中枢神经系统损伤性疾病中的作用综述如下，以期进一步明确Lingo-1在神经再生领域研究的作用和地位。Lingo-1 as a dark horse is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery in central nervous system injury. The structure, distribution and biological characteristics of Lingo-1 and its role in the central nervous system injury are collected and analyzed; the role and status of Lingo-1 in the field of nerve regeneration are further clarified. The further research of Lingo-1 will broaden the treatment method and target of new drugs in the field of nerve regeneration

关 键 词：LINGO-1 中枢神经系统损伤 神经生长抑制因子 

分 类 号：R741[医药卫生—神经病学与精神病学]