经颅磁刺激联合脑电图技术在意识障碍患者意识判别中的应用  

Transcranial magnetic stimulation combined with high-density EEG in assessment of patients with disorders of consciousness

作　　者：夏小雨[1] 杨艺[1] 白洋[2] 何江弘[1] 

机构地区：[1]北京军区总医院附属八一脑科医院,北京100700 [2]燕山大学电气工程学院,秦皇岛066004

出　　处：《中华神经医学杂志》2016年第4期425-428,共4页Chinese Journal of Neuromedicine

基　　金：（1）全军青年项目（15QNP006）（2）北京军区总医院创新培育基金（2015-LC-09）

摘　　要：对意识障碍患者意识的判别目前仍是临床难题，现阶段主要基于行为学评估，误诊率很高，非常需要客观指标协助意识判别。经颅磁刺激联合脑电图技术可以在任意给定的皮层区域施加磁刺激，同步记录大脑皮层的电反应，现已初步应用于各种生理（睡眠）、药理（麻醉）、病理（昏迷、植物状态等）条件下的意识判别，有望成为个体水平上判别区分意识水平的有效工具。本文现围绕该技术在意识障碍患者意识判别中的具体应用综述如下。Assessment of consciousness in patients with disorders of consciousness （DOC） remains a clinical challenge. It is now mainly based on behavioral evaluation, which brings lots of misdiagnoses. Objective measures of the level of consciousness are still needed. Transcranial magnetic stimulation-electroencephalogram （TMS-EEG） allows the stimulation of any given cortical areas and the recording of the immediate electrical cortical response. This technique has been successfully employed to measure the changes in brain complexity under physiological, pharmacological and pathological conditions. TMS-EEG might be a reliable tool to discriminate between conscious and unconscious patients at the single subject level.

关 键 词：经颅磁刺激 脑电图 意识障碍 

分 类 号：R741.044[医药卫生—神经病学与精神病学]