帕金森病伴发焦虑的相关因素研究  

Related Factors of Anxiety in Patients with Parkinson's Disease

作　　者：罗璨[1] 张勇[1] 黄婷婷[1] 卢祖能[1] 

机构地区：[1]武汉大学人民医院神经内科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2016年第3期457-460,共4页Medical Journal of Wuhan University

基　　金：湖北省卫计委重点项目(编号:WJ2015MA007);武汉市科技局2015年应用基础研究计划项目(编号:2015060101010047)

摘　　要：目的:探讨帕金森病(PD)伴发焦虑的相关因素。方法:采用贝克焦虑量表(BAI)将入组60例PD患者分为焦虑和非焦虑组。记录两组患者基本情况及用药情况。选用帕金森病统一评价量表(UPDRS)和改良Hoehn&Yahr(H&Y)分期评价患者运动症状;选用蒙特利尔认知评估量表(MOCA)、贝克抑郁量表(BDI)、PD睡眠量表(PDSS)、Epworth嗜睡量表(ESS)和PD自主神经症状量表(SCOPA-AUT)评价患者非运动症状。结果:基本情况及运动症状方面,焦虑组与非焦虑组间差异无统计学意义。PD药物使用方面,焦虑组金刚烷胺的日剂量及左旋多巴等效日剂量(LEDD)低于非焦虑组(P<0.05)。非运动症状方面,焦虑组BDI、PDSS和SCOPA-AUT得分高于非焦虑组(P<0.05)。回归分析示,BAI得分与BDI、SCOPA-AUT得分呈正相关,与LEDD呈负相关。结论:抑郁和自主神经功能障碍是PD焦虑的危险因素,LEDD是PD焦虑的保护因素。Objective：To explore the clinical related factors of anxiety in patients with Parkinson＇s disease（PD）.Methods：According to the scores of Beck Anxiety Inventory（BAI）,60 PD patients were divided into the anxiety group and the non-anxiety group.Demographic data and anti-Parkinson＇s medication usage of PD patients were collected.Unified Parkinson＇s Disease Rating Scale（UPDRS）and modified Hoehn and Yahr（HY）grade were used to evaluate the severity of the motor symptoms.Montreal Cognitive Assessment（MOCA）,Beck Depression Inventory（BDI）,the scale for outcomes in PD for autonomic symptoms（SCOPA-AUT）,Parkinson＇s Disease Sleep Scale（PDSS）and Epworth Sleeping Scale（ESS）were used to evaluate the non-motor symptoms.Results：In terms of the demographic data and motor symptoms,there were no significant differences between the anxiety group and the non-anxiety group.In terms of anti-Parkinson＇s medication usage,amantadine usage and L-doppa equivalent daily dose（LEDD）of patients were lower than those of patients in the non-anxiety group（P〈0.05）.Additionally,in terms of non-motor symptoms,the anxiety group had higher BDI,PDSS and SCOPA-AUT scores than those of patients in the non-anxiety group（P〈0.05）.Multiple regression analysis demonstrated that BAI score was positive correlated with BDI score and SCOPA-AUT score,but was negativecorrelated with LEDD.Conclusion：Depression and autonomic dysfunction are the risk factors of anxiety in PD,and LEDD is the protective factor of anxiety in PD.

关 键 词：焦虑 帕金森病 帕金森病药物 相关因素 

分 类 号：R741[医药卫生—神经病学与精神病学]