树突状细胞疫苗联合细胞因子诱导的杀伤细胞治疗用于预防结直肠癌术后复发转移的临床疗效观察  

Clinical Effects of Immunotherapy with Dendritic Cell Vaccine and Ctokine-induced Killer Cells in Prevention of Recurrence and Metastasis for post-Surgery Colorectal Cancer Patients

作　　者：牛静秀[1] 张利红[2] 李佳丽[1] 朱慧[1] 庞雁[1] 李维廉[1] 

机构地区：[1]天津市人民医院肿瘤科,天津300121 [2]南开大学医学院,天津300073

出　　处：《中国中西医结合外科杂志》2016年第2期112-116,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：天津市科技计划项目(12ZCDZSY17100)

摘　　要：目的：评价树突状细胞（DC）疫苗联合细胞因子诱导的杀伤细胞（CIK）用于预防结直肠癌术后转移复发的临床疗效。方法：74例大肠癌术后患者分为两组,接受自体免疫细胞治疗设为I组（24例）;未接受自体免疫细胞治疗为NI组（50例）。记录I组患者迟发型过敏皮肤测试（DTH）和发热反应情况,并对两组患者接受治疗前后生活质量、无病生存期（DFS）进行对比分析。结果：24例I组患者中,DTH阳性为12/24（50.00%）,发热反应为15/24（62.50%）;卡氏评分病人生存质量改善的在I组为8/24（33.33%）,相比较于NI组（19/50,18.00%）显著提高（χ^2=7.063 P=0.029）;Kaplan-Meier法生存期观察两组之间DFS,I组比NI组延长98 d（χ^2=4.304 P=0.038）结论：自体免疫细胞治疗早期结直肠癌,可以提高生存质量,延长复发时间。ObjectiveTo evaluate the clinical effects of immunotherapy with dendritic cells（DC）and cyto-kine-induced Killer（CIK）cells on prevention of recurrence and metastasis in post-surgery patients with colorec-tal cancer（CRC）.MethodsA total of 74 post-surgery patients with CRC were randomly divided into twogroups.24 cases who received immunotherapy with DC and CIK were defined as group I,50 cases who did notreceived the immunotherapy were defined as group NI.Delayed type hypersensitivity（DTH）skin test results andfever were abserved in Group I.Quality of life（QOL）and disease-free survival（DFS）were analyzed in bothgroups.ResultsPositive rates of DTH and fever were 12/24（50.00%）and 8/24（33.33%）respectively in groupI.Quality of life（QOL）by Karnofsky in group I was 8/24（33.33%）which was higher than that in group NI（19/50,18.00%,χ^2=7.063 P=0.029）.DFS in group I（298 days）was longer than DFS in group NI（200 days,χ^2=4.304 P=0.038）.ConclusionImmunotherapy with DC and CIK maybe improve QOL and prolong DFS inpost-surgery CRC.

关 键 词：结直肠癌 无病生存期 树突状细胞 细胞因子诱导杀伤细胞 

分 类 号：R735.3[医药卫生—肿瘤]