LRP6基因多态性与代谢综合征的相关性研究进展  

Research progress on association of LRP6 gene polymorphism and metabolic syndrome

作　　者：王振敏[1,2] 罗建权[1,2] 张伟[1,2] 

机构地区：[1]中南大学湘雅医院临床药理研究所,湖南长沙410008 [2]中南大学临床药理研究所遗传药理湖南省重点实验室,湖南长沙410078

出　　处：《中国药理学通报》2016年第5期603-607,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81273595);国家高技术研究发展计划(863计划)资助项目(No 2012AA02A518)

摘　　要：代谢综合征作为多种疾病的发病基础,发病机制复杂。近年研究发现,Wnt/β-catenin信号通路在代谢综合征的发生发展中起到重要的调控作用。低密度脂蛋白受体相关蛋白6(low-density lipoprotein receptor related protein,LRP6)作为Wnt/β-catenin信号通路的重要协同受体,已有研究表明其与代谢综合征之间存在相关性。该文将对该基因多态性及其调节机制进行深入探讨,为代谢综合征的研究治疗提供新的思路和方向。Metabolic syndrome is the fundamental factor in the pathogenesis of a variety of diseases, and it has not yet been fully understood due to its complicated mechanism. Multiple re-searches have implicated that Wnt/β-catenin signaling pathway may have a significant effect on the formation and development of metabolic syndrome. LRP6 is an important co-receptor of Wnt/β-catenin signaling pathway ,and there are some researches im-plicating the correlation between LRP6 and metabolic syndrome. The in-depth research on the gene polymorphism and its modula-tion mechanism can provide new ideas and directions for meta-bolic syndrome therapy.

关 键 词：WNT信号通路 LRP6 代谢综合征 Ⅱ型糖尿病 高血脂症 动脉粥样硬化 冠状动脉疾病 

分 类 号：R-05[医药卫生] R329.25