以IAPs为靶点的抗肿瘤研究进展  

Anti-tumor research targeting IAPs

作　　者：黄莹莹[1] 刘浩[2] 

机构地区：[1]蚌埠医学院第一附属医院药剂科 [2]蚌埠医学院药学系,安徽蚌埠233000

出　　处：《中国药理学通报》2016年第5期612-615,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81000992;81072207);安徽省高校自然科学研究项目(No KJ2015B070by);蚌埠医学院自然科学基金资助项目(No byky1451)

摘　　要：凋亡抑制因子(inhibitor of apoptosis proteins,IAPs)是一类高度保守的内源性抗细胞凋亡因子家族,主要通过抑制caspase活性和参与调节核因子NF-κB的作用抑制细胞凋亡。caspases蛋白酶的级联激活是凋亡过程的中心环节,Bcl-2家族蛋白和IAPs家族蛋白是主要控制因素。近年来发现,某些IAPs成员异常表达与肿瘤密切相关,成为肿瘤治疗的潜在靶点。因此,该文主要综述了与IAPs家族相关的蛋白以及以IAPs为靶点的抗肿瘤研究。Apoptosis inhibitors ( inhibitor of apoptosis proteins, IAPs) are a class of highly conserved apoptotic endogenous anti-cytokine family, primarily by inhibiting caspase activity and par-ticipation in regulation of nuclear factor NF-κB inhibition of ap-optosis. caspases cascade of protease activation is a central part of the apoptotic process, Bcl-2 family proteins and IAPs family proteins are the main controlling factors. In recent years, we found that abnormal expression of some IAPs members is closely associated with the tumor, a potential target for cancer therapy. Therefore, this paper reviews the major protein associated with IAPs family and anti-tumor research targeting IAPs.

关 键 词：肿瘤 凋亡 凋亡抑制因子 半胱氨酸蛋白酶 线粒体促凋亡蛋白 核因子 

分 类 号：R-05[医药卫生] R329.25