体外受精-胚胎移植受孕与自然受孕双胎妊娠临床结局比较  

Comparison of pregnancy outcomes between twin pregnancy conceived by IVF-ET and twin pregnancy conceived naturally

作　　者：周晶[1] 李博[1] 陈书强[1] 肖西峰[1] 黄剑磊[1] 孙惠君[1] 董杰[1] 王晓红[1] 

机构地区：[1]第四军医大学唐都医院生殖医学中心,西安710038

出　　处：《生殖医学杂志》2016年第4期331-335,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金(81370710;81300531)

摘　　要：目的探讨体外受精-胚胎移植（IVF-ET）对双胎妊娠母胎结局的影响。方法回顾性分析2014年1~12月于我院产科分娩的双胎妊娠产妇的临床资料。按照受孕方式分为两组：IVF-ET组（89例）和自然妊娠组（56例）。比较两组的孕产妇并发症、分娩情况及新生儿结局。结果IVF-ET组孕产妇平均年龄（30.45±4.40）岁显著高于自然妊娠组的（28.63±5.12）岁,IVF-ET组孕妇妊娠期高血压疾病发生率（25.8%）、新生儿极早产（28~31＋6周）发生率（10.1%）、极低出生体重（〈1 500g）发生率（10.1%）及转新生儿科比例（55.1%）均显著高于自然妊娠组（分别为12.5%、3.6%、3.6%和34.8%）（P均〈0.05）。结论 IVF-ET助孕的双胎妊娠发生不良妊娠结局的风险相对较高,建议临床上应加强IVF-ET术后双胎妊娠并发症的防治及产前、产时监护。Objective： To compare the obstetric and neonatal outcomes between the twin pregnancy conceived by IVF-ET and the twin pregnancy conceived naturally.Methods： The retrospective cohort study included 89 twin pregnancy conceived by IVF-ET and 56 twin pregnancy conceived naturally in Tangdu hospital during 2014.The maternal complications,childbirth and neonatal outcomes were compared between the two groups.Results： The women in the IVF-ET conceived group were older than the naturally conceived group[（30.45±4.40）vs.（28.63±5.12）]（P〈0.05）.The rate of pregnancy-induced hypertension（25.8%vs.12.5%）,the incidence of premature birth at 28-31＋6 weeks（10.1% vs.3.6%）,the very low birth weight rate（10.1% vs.3.6%）,and the ratio of referral to neonatology ICU（55.1% vs.34.8%）were significantly higher in IVF-ET conceived group than those of the naturally conceived group（all P〈0.05）.Conclusions： Twin pregnancy conceived by IVF-ET is associated with adverse pregnancy outcomes.The prevention of complications and prenatal intrapartum care after twin pregnancy conceived by IVFET should be strengthened.

关 键 词：体外受精-胚胎移植 双胎妊娠 妊娠结局 

分 类 号：R[医药卫生]