血清肿瘤标志物在胃癌术前评估的作用  

The Role of Preoperative Evaluation of Serum Tumor Markers in Gastric Cancer

作　　者：周粼[1] 王欢[1] 梁道明[1] 宛宝生[1] 王华[1] 孙锋[1] 

机构地区：[1]昆明医科大学第二附属医院胃肠外科,云南昆明650101

出　　处：《中国普外基础与临床杂志》2016年第4期425-428,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨血清肿瘤标志物CA72-4、CEA、CA199和CA125对胃癌患者术前评估的价值。方法回顾性分析昆明医科大学第二附属医院胃肠外科2013年6月至2014年6月期间收治的70例胃癌手术患者术前血清肿瘤标志物CA72-4、CEA、CA199及CA125及其临床病理资料。结果血清CA72-4浓度与肿瘤直径、TNM分期、肿瘤浸润深度及淋巴转移数目有关(P<0.05);CA199浓度与肿瘤直径、TNM分期及肿瘤浸润深度有关(P<0.05);CEA和CA125浓度与肿瘤直径、TNM分期及远处转移有关(P<0.05);上述4项指标均与患者年龄和性别无关(P>0.05)。结论血清肿瘤标志物CA72-4、CEA、CA199及CA125对胃癌术前评估具有一定的临床价值。Objective To study the preoperative evaluation value of serum tumor markers（CA72-4, CEA, CA199 and CA125） in patients with gastric cancer. Methods Serum levels of tumor markers（CA72-4, CEA, CA199 and CA125） and clinical pathological data of 70 patients with gastric cancer before operation who underwent surgical treatment in the Gastrointestinal Surgery Department of Second Affiliated Hospital of Kunming Medical University in June 2013 to 2014 June were retrospectively analyzed. Results There were some connection between the concentration of the serum CA72-4 and the tumor diameter, TNM staging, invasion depth, and the number of lymph node metastasis（P〈0.05）, between CA199 and tumor size, TNM staging, and invasion depth（P〈0.05）, between CEA, CA125 and tumor diameter, TNM staging and distant metastasis（P〈0.05）, but the CA72-4, CA72-4, CEA and CA125 had nothing to do with patient＇ age and gender. Conclusion The serum tumor markers of CA724, CEA, CA199, and CA125 have clinical application value in preoperative evaluation of gastric cancer.

关 键 词：胃癌 肿瘤标志物 术前分期 

分 类 号：R735.2[医药卫生—肿瘤]