血清缓激肽水平与阿尔茨海默病及遗忘型轻度认知障碍的临床研究  

Clinical study of serum bradykinin level in Alzheimer's disease and amnestic mild cognitive impairment

作　　者：李甜甜[1,2,3] 王海峰[2] 王新[2] 庄珊 邢成名[2] 

机构地区：[1]青岛大学医学院,山东青岛266071 [2]山东省青岛市市立医院神经内一科,山东青岛266071 [3]山东省青岛市八大湖街道巢湖路社区卫生服务中心,山东青岛266071

出　　处：《中国医刊》2016年第4期50-54,共5页Chinese Journal of Medicine

摘　　要：目的探讨血清缓激肽（bradykinin,BK）水平在阿尔茨海默病（Alzheimer＇s disease,AD）及遗忘型轻度认知障碍（amnestic mild cognitive impairment,a MCI）中的作用。方法纳入受试者132例,分为AD组、aMCI组及对照组,分析各组血清BK水平。结果与对照组（P=0.000）及a MCI组（P=0.004）相比,AD组血清BK水平显著升高。且与对照组相比,血清BK水平（OR=1.085,95%CI 1.018～1.157;P=0.013）是AD的危险因素。简易智能状态检查量表（mini-mental state examination,MMSE）及其亚项均与血清BK水平呈显著负相关。ROC分析显示曲线下面积为0.806（95%CI 0.715～0.898,P=0.000）,对AD诊断的敏感性为98%,特异性为85%。结论血清BK是AD的危险因素,且BK越高,认知功能越低。血清BK水平可能作为AD诊断的参考性生物学指标。Objective We aimed to investigate the occurrence and the role in the development of serum BK in Alzheimer,s disease（AD） and amnestic mild cognitive impairment（a MCI）. Method 132 subjects were included,and were divided into AD group a MCI group and control group. Furthermore, the level of serum BK was analyzed. Result Compared with control group（P=0.000） and a MCI（P=0.004） group, the level of serum BK in AD was significantly higher. Meanwhile, the level of serum BK was a risk factor for AD（OR=1.085, 95%CI 1.018～ 1.157; P=0.013）, and was negatively related to MMSE and its sub-items. Using ROC curve showed that the area under the curve was 0.806, 95%CI（0.715～0.898, P=0.000）, the sensitivity for the diagnosis of AD was 98%, and the specificity was 85%. Conclusion Serum BK is a risk factor for AD, and a higher BK level is at a worse cognitive decline.Serum BK may be used as biological indicators of reference of the AD diagnosis.

关 键 词：缓激肽 遗忘型轻度认知障碍 阿尔茨海默病 血清 简易智能状态检查量表 

分 类 号：R743[医药卫生—神经病学与精神病学]