进展性脑卒中相关危险因素分析  

Study of Risk Factors of Stroke in Progression

作　　者：肖萌[1] 王泽颖[2] 李超泳 李晓满[1] 

机构地区：[1]潍坊医学院神经内科教研室,山东潍坊261053 [2]潍坊市中医院神经内科 [3]潍坊市峡山生态经济发展区人民医院普外科

出　　处：《潍坊医学院学报》2016年第2期90-92,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨影响进展性脑卒中的相关危险因素。方法连续选取48h内新发缺血性脑卒中患者119例,运用美国国立卫生研究院卒中(NIHSS)量表进行评分,根据NIHSS评分的变化分为进展组和非进展组,观察项目包括:年龄、性别、身体质量指数(BMI)、既往病史、伴随症状等危险因素及诱因,入院第1天NIHSS评分、入院第1天SPIEGEL睡眠量表评分、平均SPIEGEL睡眠量表评分等评分结果及红细胞数、血小板数、血脂、血糖、肝肾功等检验结果,对各因素进行单因素分析,对2组间差异有统计学意义的自变量作多因素Logistic回归分析。结果 119例符合条件的新发缺血性脑卒中患者中进展性脑卒中患者37例(31.09%),经单因素分析,有6个自变量的差异有统计学意义,包括既往高血压病病史、既往糖尿病病史、平均SPIEGEL评分、血小板数、肌酐、尿素氮/肌酐。以脑卒中是否发生进展为因变量,对经单因素分析差异有统计学意义的自变量作多因素Logistic回归分析,结果显示:既往高血压病病史、既往糖尿病病史、平均SPIEGEL评分有显著意义,血小板数、肌酐、尿素氮/肌酐无显著性差异。既往有高血压病病史、既往有糖尿病病史、平均SPIEGEL评分较高的急性缺血性脑卒中患者出现进展的概率较高。结论高血压、糖尿病、睡眠障碍与进展性脑卒中的发生发展密切相关。Objective To analyze the risk factors that caused stroke in progression（ SIP）. Methods One hundred and nineteen consecutive cases of cerebral ischemic stroke patients who presented within 48 hours of onset were selected. All patients were evaluated by National Institute of Health stroke scale（ NIHSS）,and all of them were diagnosed as stroke in progression（ SIP） and non progression stroke（ NPS） group based on the changes of NIHSS score. Observation items include age,gender,body mass index（ BMI）,past medical history,associated symptoms,NIHSS score,SPIEGEL score,the mean SPIEGEL score,erythrocyte count,platelet count,blood lipids,blood glucose,liver and kidney function test results,etc. Univariate analysis was carried on the single factors,then we had the statistically significant factors to make multi-factor Logistic regression analysis. Results Of all the 119 cases of cerebral ischemic stroke patients,37 cases were divided into SIP,the overall incidence of SIP was 31. 09%,six factors which had significant differences,including past history of hypertension,past history of diabetes,the mean SPIEGEL score,platelet count,creatinine and urea nitrogen / creatinine. Logistic regression analysis showed： past history of hypertension,past history of diabetes and the mean SPIEGEL score were statistically significant. Acute cerebral ischemic stroke patients with past history of hypertension,past history of diabetes and the higher mean SPIEGEL score had higher risk to becoming SIP. Conclusion Hypertension,diabetes and sleep disorders are closely related to SIP.

关 键 词：脑卒中 进展性 高血压 糖尿病 睡眠障碍 

分 类 号：R743.3[医药卫生—神经病学与精神病学]