厦门居民碘营养状况与甲状腺结节关系研究  

Study on the relationship between urinary iodine and thyroid nodule in residents of Xiamen area

作　　者：戴龙[1,2] 伍啸青[1,2] 苏惠健[3] 张亚平[1] 熊润青[4] 柯金练[3] 包燕妮[4] 黄婉蓉[2] 

机构地区：[1]厦门市疾病预防控制中心,福建361021 [2]福建医科大学公共卫生学院,福州350005 [3]厦门市翔安区疾病预防控制中心,福建361102 [4]厦门市第二医院,福建361021

出　　处：《海峡预防医学杂志》2016年第1期7-8,71,共3页Strait Journal of Preventive Medicine

基　　金：福建省医学创新课题(No.2012-CXB-37)

摘　　要：目的分析厦门地区尿碘含量与甲状腺结节患病率的关系。方法采用分层整群抽样法,对277名年龄20~69岁的厦门市海边、海岛、山区居民进行甲状腺检查和尿碘检测,并进行统计分析。结果甲状腺结节患病率48.4%（134/277）,海岛55.6%（55/99）、海边50.0%（42/84）和山区39.7%（37/94）,三者差异无统计学意义;女性患病率（54.8%）高于男性（40.2%）;患病率随年龄增长而上升。尿碘中位数175.20μg/L,海岛241.40μg/L〉海边173.25μg/L〉山区129.35μg/L;甲状腺结节病例组与正常组比较,尿碘（中位数）差异无统计学意义。结论厦门地区人群尿碘水平处于适宜水平,未发现居民尿碘水平与甲状腺结节患病率存在明显关系,甲状腺结节患病率与性别和年龄相关。Objective To explore the relationship between growth differentiation factor 9（GDF-9）and bone morphogenetic protein 15（BMP-15）in human granulosa cells and ovarian response to controlled ovarian hyperstimulation.Methods Real-time PCR was applied to detect the levels of GDF-9and BMP-15 mRNA collected from 147 cases who underwent IVF（in-vitro fertilization）/ICSI（intracytoplasmic sperm injection）.The cases were stimulated with a long gonadotropin-releasing hormone agonist（GnRH-a）protocol during luteal phase.The relationship was analyzed between GDF-9,BMP-15 mRNA levels and ovarian response to gonadotropin.Results The level of GDF-9mRNA in granulosa cells was highest in high responders and lowest in poor responders.BMP-15 mRNA was significantly higher in poor response group than that in the other two groups.The numbers of retrieved oocytes were positively correlated with GDF-9mRNA level（r=0.662）and negatively correlated with BMP-15 mRNA level.The patient＇s age,antral follicle cout and GDF-9mRNA level were main influencing factors of high ovarian response by logistic regression analysis（OR=2.57,0.11,0.39）.Conclusion The expression of GDF-9and BMP-15 in granulosa cells may affect ovarian response in COH cycles.

关 键 词：碘营养 沿海居民 尿碘 甲状腺结节 

分 类 号：R151.4[医药卫生—营养与食品卫生学]