齐拉西酮治疗首发精神分裂症的临床效果观察  被引量:5

Clinical effect observation on ziprasidone in treatment of first-episode schizophrenia

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作  者:赵晶媛[1] 杨淑珍[1] 艾小青[1] 顾小静[1] 华婷婷[1] 

机构地区:[1]河南省精神病医院精神科,河南新乡453000

出  处:《社区医学杂志》2016年第7期32-35,共4页Journal Of Community Medicine

摘  要:目的探讨齐拉西酮用于治疗首发精神分裂症的临床治疗效果。方法选取2013年1月—2015年6月126例首发精神分裂症患者,随机分为两组各63例,A组采用齐拉西酮治疗,B组采用利培酮治疗。比较两组患者的临床治疗情况。计量资料比较采用重复测量资料方差分析和t检验,两两比较采用LSD法;计数资料比较进行χ2检验,P<0.05为差异有统计学意义。结果不同治疗时间患者阳性症状、阴性症状、一般精神病理评分、阳性与阴性症状量表(positive and negative syndrome scale,PANSS)总分比较,差异均有统计学意义(F=6.781、6.542、8.921、11.234,均P<0.05);两组患者阳性症状、阴性症状、一般精神病理评分、PANSS总分比较,差异均有统计学意义(F=6.824、6.643、8.974、11.241,均P<0.05)。不同治疗时间患者正确应答数、完成分类数、持续错误数、错误应答数及总应答数评分比较,差异均有统计学意义(F=24.012、17.021、20.441、26.784、32.887,均P<0.05);与治疗前比较,治疗4、8周后患者正确应答数、完成分类数、总应答数均较治疗前显著提高,差异均有统计学意义(均P<0.05)。结论齐拉西酮治疗首发精神分裂症的临床疗效与利培酮相当,其对患者执行功能的改善效果更为明显,且不良反应较少。Objective To explore the clinical effect observation of ziprasidone in treatment of first- episode schizophrenia.Methods A total of 126 first- episode schizophrenia patients were randomly divided into two groups from January 2013 to June 2015.The patients of group A were treated with ziprasidone,and group B were treated with risperidone.The clinical treatment were compared.Measurement data was processed by variance analysis of repeated measurement data and t test,pairwise comparison was used by LSD.Count data was used by chi square test,P〈0.05 was considered statistically significant.Results There were differences of the scores of positive symptom,negative symptom,general psychopathology and positive and negative syndrome scale(PANSS) in different treatment time were statistically significant(F=6.781,6.542,8.921,11.234,all P〈0.05).The differences of the scores of positive symptom, negative symptom, general psychopathology and PANSS in two groups were statistically significant(F=6.824,6.643,8.974,11.241,all P〈0.05).There were differences of the scores of positive symptom,negative symptom,general psychopathology and PANSS in different treatment time were statistically significant(F=6.781,6.542,8.921,11.234,all P〈0.05).The scores of number of correct responses,complete classification,continue errors,error response and response sdministered in different treatment time were statistical differences(F=24.012,17.021,20.441,26.784,32.887,all P〈0.05).Compared with those before treatment,the scores of number of correct responses,complete classification and response sdministered were statistical differences after 4 and8 weeks(all P〈0.05).Conclusion Ziprasidone is clinical similar efficacy with risperidone in treatment of first- episode schizophrenia,it has more obvious effect of improving the patients' executive function and fewer side effects.

关 键 词:精神分裂症 齐拉西酮 利培酮 执行功能 

分 类 号:R749.3[医药卫生—神经病学与精神病学]

 

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