AQP8在老年宫颈鳞癌患者中的表达及意义  

Expression of AQP8 Protein in Cervical Squamous Carcinoma and its Clinical Significance

作　　者：陈志铭 张宇峰 侯晓旭[2] 

机构地区：[1]鹤壁市第一人民医院,河南鹤壁458000 [2]郑州大学第一附属医院

出　　处：《中国伤残医学》2016年第7期4-5,共2页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：探讨水通道蛋白8（AQP8）在老年宫颈鳞癌患者中的表达及意义。方法：采用免疫组化染色检测AQP8在50例宫颈鳞癌、40例宫颈上皮内瘤变（ CIN）、20例正常宫颈组织中的表达。结果：AQP8在正常宫颈组织、CIN、宫颈鳞癌组织中的表达逐渐增高，差异有统计学意义（P＜0．05）；AQP8的表达与患者的年龄、肿瘤直径、临床分期无明显相关性（P＞0．05）；有淋巴结转移者宫颈鳞癌组织中AQP8的表达明显高于无淋巴结转移者，差异有统计学意义（ P＜0．05）。结论：AQP8的过表达可能在宫颈鳞癌的发生、发展、转移过程中起重要作用。Objective：To investigate the expression of AQP 8 protien in cervical squamous carcinoma and explore the relationship be-tween AQP8 protien expression and the development of the cervical squamous carcinoma .Methods：The expression of AQP8 protein in 50 cases of cervical squamous carcinoma ,40 cases of cervical intraepithelial neoplasia （ CIN） and 20 cases of normal cervices were examined by immunohistochemical technology .Results：The positive expression in parenchymal cells increasesd accompany with squamous epitheli -um malignant transformation,there were significant differences （P＜0.05）;no correlation was found between AQP8 protein expression and age ,tumor size or clinical stage （P＞0.05）.Exprission of AQP8 in cases with lymph node metastasis was higher than without lymph node metastasis （P＜0.05）.Conclusion：High expression of AQP8 may play a key role in the happen , development and lymph -node metas-tasis of cervical squamous carcinoma .

关 键 词：水通道蛋白8 宫颈鳞癌 宫颈上皮内瘤变 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]