辛可宁类生物碱催化剂的合成  

Synthesis of Cinchona Alkaloids Catalysts

作　　者：刘楝[1] 周淑晶[1] 

机构地区：[1]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《精细化工中间体》2016年第1期50-52,共3页Fine Chemical Intermediates

摘　　要：以奎尼丁为起始原料,经钯碳氢化、三乙胺/乙酰氯酰化,再由三溴化硼催化脱甲基化得到奎尼丁催化剂,3步反应总收率为74%,并对最后一步进行优化,收率由最初40%提高到89%。最终催化剂化学结构经^1H NMR及MS确证。该合成路线步骤短、条件温和,具有良好的工业应用前景。The quinidine catalyst was synthesized through a series of reactions including hydrogenation, acylation,and demethylation with a total yield of 74% using quinidine as the starting material. The structure of the final product was confirmed by ^1H NMR and MS. This synthesis route promised a good future and could be further applied in industry as being more efficient.

关 键 词：有机催化 奎尼丁 酰化 脱甲基 

分 类 号：O643.36[理学—物理化学]