中枢神经系统T细胞增殖症临床分析  

Analysis of Clinical Manifestations of T Lymphocyte Proliferative Diseases in Central Nervous System

作　　者：钱亭[1] 俞海[1] 陈向军[1] 张夏玲[2] 汪寅[2] 

机构地区：[1]复旦大学附属华山医院神经内科,200040 [2]复旦大学附属华山医院病理科,200040

出　　处：《中国临床神经科学》2016年第2期166-172,共7页Chinese Journal of Clinical Neurosciences

摘　　要：目的探讨中枢神经系统T细胞增殖症的临床表现、影像特点和病理特征以及治疗策略。方法对病理活检诊断明确的3例中枢神经系统T细胞增殖症病例进行临床资料分析。结果中枢神经系统T细胞增殖症主要临床表现为急性或亚急性起病,偏瘫、共济失调等神经系统功能缺损,但缺乏特异性表型。头颅影像学表现以脑白质病变以及脑干、小脑累及的占位性病变为主,伴有明显团块样、点状或环形强化。病理活检提示病灶中大量T细胞浸润。经过免疫抑制治疗患者预后良好。结论中枢神经系统T细胞增殖症是一种罕见的疾病,经病理活检可确诊,积极治疗预后较好,但需临床医生重视。Aim To analyze the clinical manifestations of T lymphocyte proliferative diseases, imaging and pathological features, and the treatment in central nerve system. Methods Three cases of T lymphocyte proliferative disease in central nervous system by biopsy were retrospectively analyzed. Results T lymphocyte proliferative diseases in central nervous system was manifested by acute or subacute onset, paralysis, ataxia, but lack of specific clinical features. Neuroimaging pictures were diffused with white matter and（or） brain stem and cerebellum lesions, with mass-like, point-like or ring-like enhancement. Brain biopsy indicated infiltration of a large number of T lymphocytes. Three patients improved and stabilized after immunotherapy. The prognosis seemed benign. Conclusion T lymphocyte proliferative disease of central nervous system is a rare disease which can be diagnosed by brain biopsy, and has a satisfactory prognosis after the treatment, and needs the concern of clinicians.

关 键 词：T细胞增殖症 中枢神经系统 淋巴瘤样肉芽肿 

分 类 号：R742[医药卫生—神经病学与精神病学]