急性动脉硬化性脑梗死患者颅内动脉狭窄的危险因素分析  

Analysis of Risk Factors about Intracranial Arterial Stenosis in Patients with Acute Cerebral Arteriosclerosis

作　　者：徐文苑[1] 黄经纬[1] 徐仁伵[1] 楼小亮[1] 

机构地区：[1]南昌大学第一附属医院神经内科,330006

出　　处：《中国临床神经科学》2016年第2期186-193,共8页Chinese Journal of Clinical Neurosciences

摘　　要：目的探讨脑动脉硬化合并颅内动脉狭窄的危险因素。方法选择经头颅磁共振成像(MRI)证实的148例急性脑梗死患者为研究对象,根据MRA结果分为颅内动脉狭窄组例)和无颅内动脉狭窄组例)。收集研究对象的基本情况、临床和影像学资料,检测空腹血糖、三酰甘油、胆固醇、高密度脂蛋白(HDL-C)、低密度脂蛋白、载脂蛋白、脂蛋白-a,采用单因素及多因素Logistic回归分析颅内动脉狭窄的危险因素。结果性别(P=0.037 2)、吸烟(P=0.000 1)、糖尿病史(P=0.000 4)、高血脂(P=0.005 1)、高血压病史(P=0.002 5)、脂蛋白-a(P=0.007 3)、Apo-B(P=0.047 8)是颅内动脉狭窄的危险因素;HDL-C(P=0.016 4)是颅内动脉狭窄的保护性因素。其中吸烟是第一位的、最重要的危险因素。结论吸烟、糖尿病史、高血脂、高血压病史、男性是颅内动脉狭窄的危险因素,脂蛋白-a、Apo-B、HDL-C与颅内动脉狭窄相关。危险因素越多,颅内动脉狭窄的程度越重。Aim To study the hazards of intracranial artery stenosis. Methods The patients suffering from acute cerebral infarction with intracranial artery stenosis were used as the object group to be studied. Based on the analysis of the cerebral MRA, they were divided into two groups： intracranial single artery stenosis and intracranial multiple arteries stenosis. Results Sex, smoking, diabetes, hyperlipidemia, high blood pressure, lipoprotein（mg·L-（-1））, Apo-B, HDL-C were the risk factors of intracranial artery stenosis. Conclusion Smoking, diabetes, hyperlipidemia and high blood pressure are especially dangerous factors of intracranial artery stenosis and smoking is the first and most important dangerous factor. Among the index of blood fat, lipoprotein（mg·L-（-1））, Apo-B, HDL-C are related to intracranial artery stenosis. HDL-C is a protective factor for intracranial artery stenosis. Larger value of lipoprotein（mg·L-（-1）） and Apo-B can cause the intracranial artery stenosis more easily. The more dangerous factors are combined, the intracranial artery stenosis can be caused more easily.

关 键 词：脑梗死 颅内动脉狭窄 危险因素 

分 类 号：R743[医药卫生—神经病学与精神病学]