高强度聚焦超声治疗晚期胰腺癌:疗效及预后相关因素分析  

High-intensity focused ultrasound in treatment of advanced pancreatic cancer:Effectiveness and prognostic factors

作　　者：朱衍菲[1] 赵洪[1] 张宇[1] 吉永烁[1] 朱君秋[1] 朱绫琳[1] 

机构地区：[1]复旦大学附属华东医院肿瘤科,上海200040

出　　处：《肿瘤》2016年第4期430-435,共6页Tumor

摘　　要：目的：评价高强度聚焦超声治疗晚期胰腺癌患者的有效性,并进行预后相关因素分析。方法：对80例无法手术的晚期胰腺癌患者实施高强度聚焦超声治疗,评价近期疗效;应用Kaplan-Meier法进行生存分析,计算无进展生存时间和无进展生存率;log-rank检验进行预后的单因素分析,COX回归模型进行预后的多因素分析。结果：80例患者的有效率为5.0%,疾病控制率为70.0%。中位无进展生存时间为6个月（范围：0~22个月）;6个月、1年和2年无进展生存率分别为45.0%、12.5%和0.0%。TNM分期、有无肝转移和肝功能是无进展生存的独立预后因素（P值均〈0.05）。结论：高强度聚焦超声治疗能在一定程度上延长晚期胰腺癌患者的无进展生存时间;而TNM分期、有无肝转移和肝功能是无进展生存的独立预后因素。Objective：To evaluate the effectiveness of high-intensity focused ultrasound（HIFU） therapy for patients with advanced pancreatic cancer,and investigate the prognostic factors.Methods：Eighty patients with unresectable advanced pancreatic cancer received HIFU therapy.The therapeutic response was evaluated.The Kaplan-Meier method was used to analyze the survival,and the progression-free survival（PFS） time and PFS rate were calculated.The prognostic factors were determined by log-rank test and COX regression analysis.Results：The response rate was 5.0%,and the disease control rate was70.0%.The median PFS time was 6 months（range：0-22 months）;the 6-month,1-year and 2-year PFS rates were 45.0%,12.5% and 0.0%,respectively.The multivariate analysis revealed that TNM stage,liver metastasis and liver function were independent prognostic factors（all P 〈0.05）.Conclusion：HIFU therapy can improve the PFS of patients with advanced pancreatic cancer.TNM stage,liver metastasis and liver function are independent prognostic factors related to PFS.

关 键 词：胰腺肿瘤 高强度聚焦超声 治疗结果 预后 

分 类 号：R735.9[医药卫生—肿瘤]