Alox5与髓系白血病关系的研究进展  

Progress in relationship between Alox5 and myeloid leukemia

作　　者：梅芬[1,2] 李瑞玮 杨同华[3] 撒亚莲[2] 

机构地区：[1]昆明理工大学医学院遗传学与细胞生物学系,云南昆明650050 [2]云南省第一人民医院临床基础医学研究所,云南昆明650032 [3]云南省第一人民医院国家临床重点专科血液科,云南昆明650032

出　　处：《肿瘤》2016年第4期479-484,共6页Tumor

基　　金：国家自然科学基金资助项目(编号:31460298);云南省科技计划项目(编号:2013FB203;2014FB092);云南省卫生科技计划项目(编号:2014NS271)~~

摘　　要：白血病是一组造血细胞恶性增殖并伴有分化受阻的血液系统肿瘤,其病因及发病机制尚不完全清楚,目前尚不可治愈。已有研究表明,由花生四烯酸5-脂氧合酶(arachidonate 5-lipoxygenase,Alox 5)基因编码产生的花生四烯酸代谢通路中的5-脂氧合酶(5-lipoxygenase,5-LO)影响髓系白血病的发生和发展,是靶向白血病干细胞(leukemia stem cells,LSCs)恶性生物学特性的关键分子,是髓系白血病潜在的治疗靶点。本文就Alox 5基因与髓系白血病之间的关系进行综述。Leukemia is a group of hematological malignant tumor presenting with malignant proliferation of hematopoietic cells and blocked differention,and its etiology and pathogenesis are still unclear and it is uncurable.Some studies have demonstrated that 5-lipoxygenase（5-LO） which is coded by arachidonate 5-lipoxygenase（Alox5） gene in pathway of arachidonic acid plays a key role in the occurrence and development of myeloid leukemia,and it is also a key molecule associated with malignant biological features of leukemia stem cells（LSCs） and is a potential therapeutic target for treatment of myeloid leukemia.This review summarizes the progress in relationship between Alox5 gene and myeloid leukemia.

关 键 词：白血病 髓样 肿瘤干细胞 基因 Alox5 

分 类 号：R733.7[医药卫生—肿瘤]