儿童松果体母细胞瘤术后全脑全脊髓放疗的疗效及预后分析  

Clinical features and prognosis of pinealoblastoma in children

作　　者：侯栋梁[1] 房彤[1] 宋丽楠[1] 陈力[1] 

机构地区：[1]首都医科大学附属北京世纪坛医院放疗科,北京市100038

出　　处：《中国肿瘤临床》2016年第7期298-301,共4页Chinese Journal of Clinical Oncology

摘　　要：目的：提高对儿童松果体母细胞瘤临床特征及预后的认识。方法：对2011年12月至2015年12月首都医科大学附属北京世纪坛医院放疗科收治的10例儿童松果体母细胞瘤术后患者的一般资料、肿瘤切除程度、放疗靶区和剂量以及预后进行回顾性分析。结果：10例患者均顺利完成术后全脑全脊髓放疗。全脑全脊髓中位放疗剂量为30.6（25.5~36.0）Gy,瘤床区的中位放疗剂量为55.8（50.4~60.0）Gy。4例患者在放疗结束1个月行化疗,化疗方案为依托泊苷＋顺铂＋异环磷酰胺。随访1.5~49.0个月,10例患者均获无病生存,未出现肿瘤局部复发或者脊髓播散。结论：松果体母细胞瘤是比较少见的中枢神经系统恶性肿瘤,容易出现脊髓播散。手术、术后全脑全脊髓放疗加辅助化疗的综合治疗模式是目前标准的治疗方法。综合治疗的疗效尚可,预后满意。objective： To investigate the clinical features and prognosis of pinealoblastoma in children. Methods： The clinical data of 10 patients with pinealoblastoma were retrospectively analyzed. These patients were admitted to the Department of Radiation Oncology,Beijing Shijitan Hospital, Capital Medical University from December 2011 to December 2015. Results： This study included 10 patients,with 8 males and 2 females, with a median age of 7 years. Of the 10 patients, 5 underwent gross total resection and 5 underwent subtotal resection. The 10 patients were exposed to craniospinal irradiation after surgery. The median doses of craniospinal irradiation and tumor bed were 30.6（25.5-36） Gy and 55.8（50.4-60） Gy, respectively. Of the 10 patients, 4 underwent chemotherapy 1 month after radiotherapy. The median follow- up period was 16.5（1.5- 49） months. The 10 patients survived. No local and distant recurrences were observed. Conclusion： Pinealoblastomas are rare, malignant, and pineal regional lesions that can metastasize along the neuroaxis. Surgery combined with adjuvant radiotherapy and chemotherapy should be applied to patients with pinealoblastoma. Prognosis is also favorable.

关 键 词：松果体母细胞瘤 全脑全脊髓放疗 预后 

分 类 号：R739.4[医药卫生—肿瘤] R730.55[医药卫生—临床医学]