龙胆总苷提取物掩味树脂复合物的制备  

Preparation of the resin complexes masking bitterness of Gentianae Radix total glycosides extract

作　　者：向志芸 李小芳[1] 朱宁[1] 周维[1] 李培培[1] 

机构地区：[1]成都中医药大学药学院,中药材标准化教育部重点实验室,四川省中药资源系统研究与开发利用重点实验室--省部共建国家重点实验室培育基地,四川成都611137

出　　处：《中成药》2016年第4期785-790,共6页Chinese Traditional Patent Medicine

基　　金：四川省教育厅重点项目(15ZA0094)

摘　　要：目的制备龙胆总苷提取物的掩味树脂复合物。方法以Amberlite IRA-400阴离子交换树脂为药物载体,制备龙胆总苷提取物;以药物质量浓度、树脂与药物的比例、反应温度为指标,优选掩味树脂复合物的制备方法。然后,运用差示扫描量热法(DSC)和傅里叶变换红外光谱法(FTIR)对其进行表征。结果在335℃处,出现了吸热峰和红外图谱的改变,表明复合物是通过化学作用而结合。最佳制备条件为溶液质量浓度8 mg/m L,树脂与药物的比例1.5∶1,反应温度45℃。结论该复合物能有效掩盖龙胆总苷的苦味。AIM To prepare the resin complexes masking bitterness of Gentianae Radix total glycosides extract. METHODS With Amberlite IRA-400 anion exchange resin as drug carrier,the Gentianae Radix total glycosides extract was prepared. With drug concentration,ratio of resin to drug and reaction temperature as indices,the preparation of resin complexes masking bitterness was optimized. Then they were characterized by differential scanning calorimetry（ DSC） and Fourier transform infrared spectroscope（ FTIR）. RESULTS At 335 ℃,the endothermic peak and change of infrared spectrum appeared,which showed that the complexes were combined by chemical action. The optimized preparation conditions were the solution concentration of 8 mg/m L,the ratio of resin to drug of 1. 5 ∶ 1,and the reaction temperature of 45 ℃. CONCLUSION These complexes can effectively mask the bitterness of Gentianae Radix total glycosides.

关 键 词：龙胆总苷提取物 掩味 树脂复合物 DSC FTIR 

分 类 号：R944[医药卫生—药剂学]