群体性侵袭与肿瘤的研究进展  

Research progression of collective invasion in tumors

作　　者：薛同春[1] 叶胜龙[1] 

机构地区：[1]复旦大学附属中山医院肝癌研究所,上海200032

出　　处：《临床肿瘤学杂志》2016年第3期278-281,共4页Chinese Clinical Oncology

摘　　要：群体性侵袭是肿瘤细胞重要的运动形式之一,其在肿瘤侵袭转移过程中的作用日益受到关注。群体性迁移是胚胎发育过程中重要的运动模式。与此相似,近年来研究显示癌细胞以群体方式侵袭转移在恶性肿瘤中普遍存在。群体性侵袭参与癌细胞播散和转移的机制正逐渐被揭示。对肿瘤群体性侵袭的深入研究,有助于发现新的抑制肿瘤侵袭转移的干预途径。Collective invasion is one of the main movement styles of tumor cells. The roles of the collective migration of tumor cells in invasion and metastasis are attracting attention. Collective migration is the important movement pattern in the embryos develop-ment. Similarly, accumulating evidence suggests that the collective invasion is common style in malignancies. The potential mechanisms that collective invasion participates into spreading and metastasis of tumor cells are being revealed. The intensive research on collective cell invasion of cancer cells may be helpful to find the new therapeutic method for suppressing invasion and metastasis.

关 键 词：肿瘤 群体性侵袭 细胞迁移 细胞运动 

分 类 号：R73[医药卫生—肿瘤]