单纯化疗和化疗加生物免疫治疗对转移性前列腺癌的临床疗效及安全性比较  

Clinical efficacy and safety of chemotherapy alone versus chemotherapy plus biological immunotherapy for treating metastatic prostate cancer

作　　者：赵斌[1] 李支尧[2] 张志平[3] 李瑞乾[1] 王启林[1] 雷永虹[1] 张国颖[1] 

机构地区：[1]云南省肿瘤医院昆明医科大学第三附属医院泌尿外科,云南昆明650118 [2]云南省肿瘤医院昆明医科大学第三附属医院超声诊断科,云南昆明650118 [3]云南省肿瘤医院昆明医科大学第三附属医院放射科,云南昆明650118

出　　处：《中国临床研究》2016年第4期476-479,共4页Chinese Journal of Clinical Research

基　　金：云南省科技计划项目(2014FB068)

摘　　要：目的探讨化疗加生物免疫治疗对转移性前列腺癌的临床疗效及安全性。方法收集2010年1月1日至2014年12月31日住院治疗的85例转移性前列腺癌病例的临床资料,按治疗方法的不同将其分为单纯化疗组(38例)和化疗加生物免疫治疗组(47例),对比分析单纯化疗和化疗加生物免疫治疗转移性前列腺癌的临床疗效、免疫组织细胞反应、化疗副反应以及患者化疗后的生活质量。结果治疗后,单纯化疗组的客观缓解率为60.5%,化疗加生物免疫治疗组的客观缓解率为80.9%,两组比较差异有统计学意义(P<0.05)。治疗后两组患者外周血T淋巴细胞亚群中总T淋巴细胞、T辅助细胞、T抑制细胞、自然杀伤细胞、自然杀伤性T细胞百分率均高于治疗前(P均<0.05),且化疗加生物免疫治疗组均高于单纯化疗组(P均<0.05)。单纯化疗组患者化疗后倦怠乏力、食欲不振、疼痛感和虚汗失眠发生率均较治疗前有所增加,但差异无统计学意义(P均>0.05)。化疗加生物免疫治疗组化疗后上述情况均较治疗前以及单纯化疗组治疗后明显改善(P均<0.05)。结论化疗加生物免疫治疗能明显提高转移性前列腺癌的治疗缓解率,有效提升免疫功能细胞活性,降低化疗副反应,改善患者治疗后的生活质量。Objective To explore the clinical efficacy and safety of chemotherapy plus biological immunotherapy for the treatment of metastatic prostate cancer. Methods Case data of 85 metastatic prostate cancer patients of inpatient treatment were collected. The patients were divided into chemotherapy alone group（ n = 38） and chemotherapy plus biological immunotherapy group（ n = 47） according to the treatment method. The clinical efficacy,the response of immune tissue cells,side effects of chemotherapy and patients’ quality of life（ QOL） after chemotherapy in two groups were analyzed and compared.Results After treatment,there was significant difference in objective remission rate（ ORR） between chemotherapy alone group and chemotherapy plus biological immunotherapy group（ 60. 5% vs 80. 9%,P 〈 0. 05）. After treatment,the percentage of total T lymphocyte,helper T cell（ Th）,T suppressor cell（ Ts）,natural killer cell（ NK） and natural killer T cell（ NKT） in peripheral blood in two groups increased significantly（ all P 〈 0. 05）,and they in chemotherapy plus biological immunotherapy group were significantly higher than those in chemotherapy alone group（ all P 〈 0. 05）. After chemotherapy,the incidences of fatigue,anorexia,pain and sweating insomnia in chemotherapy alone group were all higher than those before chemotherapy,but there were no significant differences in them compared with pre-treatment（ all P 〉 0. 05）. The incidences of aforementioned symptoms after chemotherapy in chemotherapy plus biological immunotherapy group significantly improved compared with pre-chemotherapy and chemotherapy alone group（ all P 〈 0. 05）. Conclusions The chemotherapy plus biological immunotherapy can obviously raise remission rate of metastatic prostate cancer,effectively elevate activity of immune function cells,decrease side effects of chemotherapy and improve patients’ QOL after treatment.

关 键 词：前列腺癌 转移性 化疗 生物免疫治疗 疗效 安全性 生活质量 

分 类 号：R737.25[医药卫生—肿瘤]