E-cadherin与脑膜瘤分级及瘤周水肿的关系  

Relationship of E-cadherin with the pathological grade of meningioma and peritumoral brain edema in patients with meningioma

作　　者：邓学云 刘毅[1] 范润金 刘丽华 夏祥国 

机构地区：[1]南充市中心医院神经外科,四川637000 [2]南充市中心医院老年病科,四川637000 [3]西南医科大学附属医院神经外科,四川泸州646000

出　　处：《中国临床神经外科杂志》2016年第4期213-215,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨上皮钙粘附蛋白(E-cad)与脑膜瘤病理分级及瘤周水肿之间的关系。方法收集2013年1月至2015年1月经手术切除及病理组织学证实的脑膜瘤标本66例,另取15例颅脑损伤后行内外减压术的正常蛛网膜组织作为对照。采用免疫组织化学方法检测E-cad的表达;头颅MRI评估瘤周水肿的程度。结果正常蛛网膜组织E-cad表达强度明显高于脑膜瘤组织(P<0.05)。脑膜瘤E-cad蛋白表达强度与脑膜瘤病理级别呈负相关(rs=-0.577;P<0.01)。脑膜瘤E-cad蛋白表达强度与瘤周水肿级别呈负相关(rs=-0.668,P<0.01)。结论 E-cad可能与脑膜瘤瘤周水肿的形成有关。Objective To explore the relationship of epithelial cadherin（E-cad） with the pathological grades of meningiomas and peritumoral brain edema（PTBE）.Methods The expression of E-cad was determined by immunohistochemical technique in 66 cases of meningiomas tissues, including 53 pathological grade Ⅰ meningiomas, 7 grade Ⅱ and 6 grade Ⅲ, and 15 cases of normal arachnoid tissues. The grades of PTBE were assessed by MRI.Results The level of E-cad expression was significantly higher in the arachnoid tissues than that in the meningioma tissues（P〈0.05）. The level of E-cad expression was significantly higher in the grade Ⅰ meningioma tissues than those in the grades Ⅱ and Ⅲ meningiomas tissues（P〈0.05）. The levels of E-cad expression in the meningiomas tissues were negatively related to the meningioma grades（rs=-0.577, P〈0.01）. The levels of E-cad expression in the meningioma tissues were negatively related to the peritumoral edema grades（rs=-0.668, P〈0.05）.Conclusion It is suggested that the down-regulation of the level of E-cad expression may be associated with the formation of peritumoral edema in the patients with meningiomas.

关 键 词：脑膜瘤 瘤周水肿 上皮钙粘附蛋白 相关性 

分 类 号：R739.41[医药卫生—肿瘤] Q786[医药卫生—临床医学]