代谢物感知失调的分子致病机理  

Metabolite-Sensing and Human Diseases

作　　者：赵健元[1] 赵世民[1] 

机构地区：[1]复旦大学生命科学学院,遗传工程国家重点实验室,遗传与发育协同创新中心,上海200438

出　　处：《中国科学：生命科学》2016年第4期392-396,共5页Scientia Sinica(Vitae)

基　　金：国家重大基础研究发展计划(批准号:2012CB910103,2013CB531200,2013CB945100,2013CB911204,2015AA020913);国家自然科学基金(批准号:31330023,81301717,81471454);科技部重大国际合作项目(批准号:2014DFA30630);上海市领军人才计划资助

摘　　要：代谢是最基础的生命活动.生物代谢网络由代谢酶和代谢物共同构成.相对于对代谢酶性质的深刻认识,对代谢物生理重要性的认识停留在物质代谢与能量代谢的水平.近年来,本研究组及国际上其他实验室的工作发现,代谢物具有信号传导功能.细胞内的代谢物水平通过不同的机制被感知,其信号通过不同的化学基础在蛋白质间相互传递并调控包括代谢、表观遗传和信号通路等重要生理过程.代谢物的失调也因此通过这些生理改变而导致人类疾病.本文对本研究组近年来在该领域的相关进展进行综述并讨论其理论及转化价值.Metabolism involves basal life-sustaining activities within living cells, including energy production and biomass construction. Biological metabolic networks are composed of both metabolic enzymes and metabolites. Compared with a deep understanding of the properties of metabolic enzymes, knowledge regarding the significance of metabolites remains on the level of substance and energy metabolism processes. In recent years, our group and other labs worldwide have found that metabolites play important roles in signal transduction. Intracellular metabolite levels can be sensed by diverse mechanisms. Metabolite signals transfer between proteins through different chemical routes and regulate a series of important physiological processes such as metabolism, epigenetics, and signaling pathways. Metabolite disorders cause human diseases by causing physiological changes in these processes. We review our recent related progress and discuss the theoretical and transformative value of the current knowledge.

关 键 词：代谢物感知 中间代谢物 信号通路 

分 类 号：R363[医药卫生—病理学]