天然产物Brosimacutins H和I的对映选择性全合成  

First Enantioselective Synthesis of Brosimacutins H and I

作　　者：叶子平[1] 杨金会[1] 冯尧[1] 马涛[1] 牛明杰[1] 

机构地区：[1]宁夏大学化学化工学院宁夏大学天然气转化国家重点实验室培育基地,银川750021

出　　处：《有机化学》2016年第3期547-554,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21362025);教育部"新世纪优秀人才支持计划"(No.NCET-09-0860)资助项目~~

摘　　要：Brosimacutins H和I是从巴西的Brosimum acutifolium Huber树皮中分离出的两个具有相似结构的黄酮类化合物.此树皮被巴西当地居民作为抗发炎和抗风湿的药物,并且这两种化合物具有一定的细胞活性.以廉价的羟苯乙酮和羟苯甲醛为原料完成了黄酮化合物Brosimacutins H和I的对映选择性合成.所有新化合物的结构都经过NMR,HRMS确认.Brosimacutins H and I, isolated from the bark of brosimum acutifolium huber, are flavanoid compounds with similar structures. The bark of this plant is used in Brazilian folk medicine as an anti-inflammatory and anti-rheumatic agent, and cellular activities were reported for these two compounds. Herein the first enantio-selective synthesis of brosimacutins H and I from cheap starting material hydroxyl-acetophenone and hydroxyl benzene formaldehyde was reported. All new compounds in this study were confirmed by NMR and HRMS.

关 键 词：brosimacutin 异戊烯基黄酮 查尔酮 二氢查尔酮 全合成 

分 类 号：O629[理学—有机化学]