缺血性卒中患者急性期氧化应激水平的临床观察  

Clinical observation of oxidative stress levels in patients with ischemic stroke acute phase

作　　者：赵野[1] 金美善[1] 胡媛[1] 朱恩波[1] 姜美子[1] 

机构地区：[1]延边大学附属医院,吉林延吉133000

出　　处：《吉林医学》2016年第4期800-803,共4页Jilin Medical Journal

摘　　要：目的：通过急性缺血性卒中患者ox-LDL水平,观察患者发生卒中后的氧化应激情况。方法：收集延边大学附属医院2014年2月~2014年5月诊断为急性缺血性脑卒中的住院患者186例,进行ox-LDL检测及相关因素（包括SSS-TOAST、NIHSS、CRP、LDL、DBIL、UA）分析研究,评价急性缺血性脑卒中患者ox-LDL与SSS-TOAST的关系、评价NIHSS评分与UA、CRP、DBIL、ox-LDL的关系。结果：1急性缺血性脑卒中患者ox-LDL与SSS-TOAST分型的差异性比较：大动脉粥样硬化类型与小血管闭塞类型、病因不确定类型间的ox-LDL差异均有统计学意义（P〈0.05）;心源性栓塞类型与病因不确定类型间ox-LDL差异均有统计学意义（P〈0.05）。2神经系统NIHSS评分与UA、CRP、DBIL、ox-LDL的差异性比较：NIHSS评分分轻度、中度、重度三组,CRP在轻度、中度间差异无统计学意义（P﹥0.05）,轻度、中度与重度之间差异均有统计学意义（P〈0.05）;UA在轻度、中度、重度之间差异均有统计学意义（P〈0.05）;ox-LDL在轻度、中度、重度之间均有统计学意义（P〈0.05）;DBIL在轻度、重度之间有差异有统一计学意义（P〈0.05）。结论：1ox-LDL与缺血性脑卒中分型中大动脉粥样硬化型密切相关。2ox-LDL与急性缺血性脑卒中严重程度相关。3CRP是ox-LDL水平的独立预测因子。Objective To observe the conditions of oxidative stress after stroke onset via the ox- LDL level in patients with acute ischemic stroke. Method One hundred and eight- six patients hospitalized and diagnosed as acute ischemic stroke in Yanbian University Affiliated Hospital from February 2014 to May 2014 were enrolled,The ox- LDL test and relative factors were analyzed and studied（ including SSS- TOAST,NIHSS,CRP,LDL,DBIL,UA）. The correlation between ox- LDL in patients with acute ischemic stroke and types of strokes; the correlation between nervous system NIHSS score and UA,CRP,DBIL and ox-LDL. Results 1The correlation between ox- LDL in patients with acute ischemic stroke and types of strokes： There were differences among the large- artery atherosclerosis,small artery occlusion and patients with uncertain etiology（ P〈0. 05）,while there were differences between ox- LDL in cardiogenic embolism and patients with uncertain etiology（ P〈0. 05）. 2Correlation between nervous system NIHSS score and UA,CRP,DBIL and ox- LDL： NIHSS score was classified as three groups,including mild,medium and sever groups. CRP had no differences between mild and medium groups and had no differences among mild,medium and severe groups（ P〈0. 05）. UA had differences among mild,medium and severe groups（ P〈0. 05）. Ox- LDL had differences among mild,medium and severe groups（ P〈0. 05）. DBIL had differences between mild and severe groups（ P〈0. 05）. Conclusion 1ox- LDL is closely related to the Large- artery atherosclerosis of acute ischemic stroke. 2ox- LDL is closely related to acute ischemic stroke. 3CRP are independent predictive factors for ox- LDL.

关 键 词：急性缺血性脑卒中 OX-LDL NIHSS评分 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]