微波消融治疗>70岁早期肝细胞肝癌患者效果分析  

Effect analysis of microwave ablation therapy for early hepatocellular carcinoma in patients over 70 years old

作　　者：许贇[1] 沈强[1] 王能[1] 刘沛[1] 盛月红[1] 许芸芸[1] 钱国军[1] 

机构地区：[1]第二军医大学附属东方肝胆外科医院微创一科,上海200438

出　　处：《介入放射学杂志》2016年第4期332-336,共5页Journal of Interventional Radiology

基　　金：国家"十二五"科技重大专项(2012ZX10002016)

摘　　要：目的评估微波消融(MWA)治疗>70岁早期肝细胞肝癌(HCC)患者的效果,分析预后相关因素。方法 2009年1月至2011年1月,第二军医大学东方肝胆外科医院收治的67例老年早期HCC患者接受了超声引导下经皮MWA治疗。结果肿瘤完全消融率为97.3%,1、3、5年总生存率分别为92.5%、73.0%、50.1%;1、3、5年无瘤生存率分别为76.1%、47.8%、34.3%。结论 MWA是治疗老年早期HCC患者安全有效的方式。丙型肝炎病毒感染和肿瘤直径≥3 cm是影响无瘤生存率的独立危险因素,肿瘤直径≥3 cm是影响总生存率的独立危险因素。Objective To investigate the effect of microwave ablation （MWA） therapy for early stage hcpatoeellular carcinoma （HCC） in patients over 70 years old and to analyze the factors related to prognosis. Methods During the period from January 2009 to January 2011, a total of 67 elderly patients with early stage HCC were admitted to Oriental Hepatobiliary Surgery Hospital of Second Military Medical University to receive ultrasound-guided percutaneous MWA therapy. The complete ablation rate, overall survival rate, disease-free survival rate were calculated and the prognostic risk factors were analyzed. Results The complete ablation rate of tumor was 97.3%. The one-year, 3-year and 5-year overall survival rates were 92.5%, 73.0% and 50.1% respectively; the corresponding disease-free survival rates were 76.1%, 47.8% and 34.3% respectively. Conclusion For the treatment of early stage HCC in elderly patients, microwave ablation is safe and effective. Hepatitis C virus infection and tumor diameter ≥3 cm are independent risk factors influencing disease- free survival rate, while tumor diameter ≥ 3 cm is an independent risk factor affecting the overall survival rate.

关 键 词：肝细胞肝癌 微波消融 老年患者 预后 

分 类 号：R735.7[医药卫生—肿瘤]