细胞角蛋白在腺癌诊断中的作用  

Role of Cytokeratins in Diagnosis of Adenocarcinoma

作　　者：黄冬云[1] 许文景[2] 徐兴祥[2] 张旭东[1] 周锐[3] 

机构地区：[1]江苏省苏北人民医院老年科,江苏扬州225001 [2]江苏省苏北人民医院呼吸内科,江苏扬州225001 [3]中南大学湘雅二医院呼吸内科,长沙410011

出　　处：《医学综述》2016年第8期1499-1502,共4页Medical Recapitulate

摘　　要：细胞角蛋白(CK)主要分布在上皮细胞胞质中,其主要功能是维持上皮细胞的完整性及连续性,是上皮细胞及分化的标志。在细胞恶性转化和癌症发生过程中CK的表达基本保持不变,但上皮来源恶性肿瘤或转移瘤能高度表达CK,而间叶组织不表达CK,依据其对肿瘤进行分类,在临床诊断中具有重要价值。CK异常表达与肿瘤的各种生物学行为有密切关系。CK在上皮恶性肿瘤中作为有价值的诊断标志物是其最普遍的应用。根据组织来源不同,上皮组织恶性肿瘤分为腺癌、鳞状细胞癌、基底细胞癌及移行细胞癌。Cytokeratins（ CK） are mainly distributed in the cytoplasm of epithelial cells,and their main function is to maintain the integrity and continuity of the epithelial cells. CK are the characteristic symbols of epithelial cells and their differentiation. In the process of the malignant transformation of cells and the formation of cancer,CK expression remains the same basic phenotype. Malignant tumors of epithelial origin or related metastases can highly express CK,but mesenchymal tissue does not express CK. According to the above rules,we can classify different malignant tumors by different classifications of CK. As tumor markers,CK play a very important part in clinical diagnosis of cancers. There is a close relationship between the abnormal expression of CK and the biological behavior of tumors. The basic and the most common application of CK is a valuable diagnostic marker in epithelial malignant tumors. According to the different histologic origin,epithelial malignant tumors can be divided into adenocarcinoma,squamous cell carcinoma,basal cell carcinoma and urothelial carcinoma.

关 键 词：腺癌 细胞角蛋白 诊断 

分 类 号：R734.2[医药卫生—肿瘤]