胎球蛋白A与中枢神经系统相关疾病的研究进展  

The Research Advance of Fetuin-A in the Central Nervous System Related Diseases

作　　者：向英[1] 陈莉芬[1] 

机构地区：[1]重庆医科大学附属第二医院神经内科

出　　处：《医学综述》2016年第8期1533-1536,共4页Medical Recapitulate

摘　　要：胎球蛋白A(FA)是由肝脏分泌的急性时相蛋白,可参与炎症反应、抑制血管钙化等多种生物学作用。FA与急性缺血性卒中密切相关,同时,FA因其抗炎作用,在多发性硬化患者脑脊液中升高,且在疾病的活动期升高更显著,可作为评定其治疗效果的指标。此外,随着对FA研究的深入,发现FA与其他中枢神经系统疾病(如偏头痛、阿尔茨海默病)也有相关性。The fetuin-A（ FA） is an acute phase protein secreted by the liver,involved in the inflammatory response and inhibition of vascular calcification and so on. FA showed a significant association with ischemic stroke. FA is increased in serum and cerebrospinal fluid in multiple sclerosis,and its activity is increased more obviously in the active phase,therefore FA may be used to assess the treatment effect. Along with the further study of FA,it＇s found that FA is also correlate with other diseases of the central nervous system,such as migraine,Alzheimer disease.

关 键 词：缺血性卒中 偏头痛 阿尔茨海默病 多发性硬化 胎球蛋白A 

分 类 号：R741.02[医药卫生—神经病学与精神病学]