BRM基因多态与食管鳞状细胞癌易感性的关联研究  

Association between single nucleotide polymorphisms in BRM and the susceptibility of esophageal squamous cell carcinoma

作　　者：陈斌[1] 朱勇 张舒龙[3] 

机构地区：[1]安徽省来安县人民医院影像科,239200 [2]安徽省来安县家宁医院外科,239200 [3]江苏省东南大学附属中大医院普外科,江苏南京210009

出　　处：《蚌埠医学院学报》2016年第2期152-154,158,共4页Journal of Bengbu Medical College

摘　　要：目的：研究BRM-741位点和BRM-1321位点的插入/缺失多态与中国汉族人群食管鳞状细胞癌（ESCC）易感性的关系。方法：采用病例-对照研究,以聚合酶链反应-聚丙烯酰胺凝胶电泳的方法,分析343例ESCC患者和362名性别、年龄等人口学特征与病例频数匹配的健康对照者的BRM-741以及BRM-1321基因型分布情况。logistic回归分析BRM基因多态与ESCC易感性的关系。结果：BRM-741多态与ESCC的患病风险无相关性（P〉0.05）,而BRM-1321多态与ESCC的发生有相关性（P〈0.01）。携带BRM-1321插入/插入基因型的个体发生ESCC的风险较携带BRM-1321缺失/缺失基因型者增加了94.0%（OR=1.94,95%CI=1.11~3.38）。与缺失型等位基因比较,插入型等位基因增加了35.0%的ESCC易感性（OR=1.35,95%CI=1.07~1.71）。结论：BRM-1321多态与中国汉族人群ESCC遗传易感性有关,BRM-741基因多态与中国汉族人群ESCC的患病风险无关。Objective： To investigate the association of indel polymorphisms of BRM-741 and BRM-132 with the susceptibility of esophageal squamous cell carcinoma（ ESCC） in Chinese Han population. Methods： The genotype distribution of BRM-741 and BRM-1321 in 343 cases of ESCC and 362 healthy controls whose gender,age and other demographic characteristics were matched with the frequency of the ESCC cases was analyzed in a case-control study by using polymerase chain reaction-polyacrylamide gel electrophoresis method. Logistic regression model was used to evaluate the association between polymorphisms and ESCC susceptibility. Results： There was no significant association between BRM-741 and ESCC（ P 〉0. 05）. However,there was a significant association between BRM-1321 and ESCC susceptibility（ P 〈0. 01）. The insertion / insertion genotype was associated with an increased risk of ESCC compared with the deletion / deletion genotype of BRM 1321（ OR = 1. 94,95% CI = 1. 11- 3. 38）. The insertion allel was associated with an increased risk of ESCC compared with the deletion allel of BRM 1321（ OR = 1. 35,95% CI = 1. 07- 1. 71）. Conclusions： The polymorphism in BRM-1321 is associated with ESCC susceptibility,but no significant association is observed between the polymorphism in BRM-741 and ESCC incidence in Chinese Han population.

关 键 词：食管肿瘤 癌 鳞状细胞 BRM基因 基因多态 

分 类 号：R735.1[医药卫生—肿瘤]