国际肺癌研究协会第八版国际肺癌TNM分期修订稿解读  

An Interpretation of Revised Version of International Association for Study of Lung Cancer for Forthcoming 8th Edition of TNM Classification for Lung Cancer

作　　者：张用[1] 毕建平[1] 皮国良[1] 曾凡玉[1] 韩光[1] 胡德胜[1] 

机构地区：[1]湖北省肿瘤医院放疗中心,武汉430079

出　　处：《肿瘤防治研究》2016年第4期313-318,共6页Cancer Research on Prevention and Treatment

基　　金：湖北省卫计委青年人才项目(WJ2015Q027);武汉市科技局应用基础研究项目(2015060101010054)

摘　　要：肺癌导致的死亡人数位于各类恶性肿瘤之首,它是对人类健康和生命威胁最大的恶性肿瘤之一。肺癌的TNM分期系统描述了肺癌的生长和扩散等信息,对于指导其临床治疗起了非常重要的作用。目前临床上广泛采用的是国际抗癌联盟(Union for International Cancer Control,UICC)和美国癌症联合会(American Joint Committee on Cancer,AJCC)于2009年发布的第七版肺癌TNM分期。随着肺癌综合治疗的发展以及临床实践模式的改变,肺癌的疗效及其预后也有了明显的改变,旧的分期标准可能难以满足目前的临床需求。因此,国际肺癌研究协会(international association for the study of lung cancer,IASLC)于2014年就开始进行最新一轮的肺癌TNM分期标准修订研究计划。本次分期研究克服了以往分析数据均为回顾性数据的缺陷,采用囊括了回顾性和前瞻性数据的新数据库。该数据库主要是由1999—2010年间新确诊的94 708名肺癌患者数据组成。通过对该数据库分析研究,国际肺癌研究协会对TNM分期进行了相应的修改,并最终在2015年发表了第八版国际肺癌TNM分期的修订稿。本文就该修订稿的细节进行解读。Lung cancer is the leading cause of deaths from all cancers worldwide. TNM staging system can describe the information of the growth and spread of lung cancer, and it also plays a very important role in guiding the clinical treatment. The 7th edition of the TNM staging of lung cancer being widely used in worldwide was published by the Union for International Cancer Control（UICC） and American Joint Committee on Cancer（AJCC） in 2009. However, with the development of treatment for lung cancer, prognosis of lung cancer after the treatment would be significantly changed, and the 7th edition staging may be difficult to meet current clinical needs. Therefore, the International Association for the Study of Lung Cancer（IASLC） started a research to establish objectives for the T, the N, and the M components to inform the 8th edition of the TNM classification of lung cancer in 2014. Despite the large number of patients, not all descriptors could be validated. This prompted a new collection of retrospective and prospective data to overcome the limitations of the original retrospective database. The new IASLC database has information on 94 708 new patients diagnosed of lung cancer between 1999 and 2010. After analysis of the new database, IASLC formed the basis of recommendations to the UICC and AJCC for the revision of the 7th edition of TNM classification of lung cancer. They published the revised version of the 8th edition of TNM classification of lung cancer in 2015. This article would like to try to interpret this revision in details.

关 键 词：肺癌 TNM分期 国际肺癌研究协会 第八版修订稿 

分 类 号：R734.2[医药卫生—肿瘤]