外伤性脑出血患者术后病原菌感染对神经生长因子及抑瘤素M水平的影响研究  

Pathogen distribution and effect on NGF and oncostatin M in patients with traumatic cerebral hemorrhage complicated by postoperative infection

作　　者：徐剑峰[1] 曾令勇[1] 刘阳[1] 吴贵强[1] 张海[1] 杨华东[1] 高阳[1] 邓李[1] 张波[1] 张鹏[1] 曹辉[1] 

机构地区：[1]绵阳市第三人民医院神经外科,四川绵阳621000

出　　处：《中华医院感染学杂志》2016年第8期1755-1757,共3页Chinese Journal of Nosocomiology

基　　金：四川省卫生厅科学研究基金资助项目(020242)

摘　　要：目的分析外伤性脑出血患者术后感染病原菌分布,并探讨感染后患者血清中神经生长因子和抑瘤素M水平的变化,为临床治疗提供参考依据。方法对2011年2月-2014年7月诊治的160例外伤性脑出血感染患者设为感染组,分析患者感染后血清中神经生长因子和抑瘤素M水平的变化,同期选取健康体检者160名为对照组,外伤性脑出血未感染患者160例为未感染组,对比3组抑瘤素M变化,数据采用SPSS 20.0软件进行统计分析。结果 160例感染患者主要感染部位以呼吸道感染为主,共33例占20.63%;共分离病原菌160株,以革兰阴性菌为主,共83株占51.88%;感染病原菌后患者神经生长因子、表皮生长因子、转化生长因子及抑瘤素M水平明显降低,且与对照组和未感染组患者比较差异有统计学意义(P<0.05)。结论外伤性脑出血患者术后容易感染,且感染后患者血清中神经生长因子及抑瘤素M水平明显降低。OBJECTIVE To explore the pathogen distribution and effects on NGF and oncostatin M in patients with traumatic cerebral hemorrhage complicated by poperative infection.METHODS Totally 160 cases of infected patients with traumatic cerebral hemorrhage in our hospital from Feb.2011 to Jul.2014 were enrolled as the infection group in this research.The pathogen distribution and serum NGF and oncostatin M were detected by ELISA.Another 160 cases of healthy subjects and 160 cases of non-infected brain traumapatients during the same period were taken as the control group and the non-infection group.Changes in oncostatin M level were compared amoly the three groups.Data were statistically analyzed by software SPSS 20.0.RESULTS The main infected site was respiratory tract,found in 33（20.63%）cases among the 160 infected cases.Totally 160 strains of pathogens were isolated from the 160 infected patients,mainly including 83（51.88%）gram-negative strains.The results also revealed that the serum NGF,EGF,oncostatin M and TGF were decreased greatly after infection,with significant differences compared with the control group and the non-infection group（P〈0.05）.CONCLUSIONPatients with traumatic cerebral hemorrhage are prone to infection after surgery.NGF and oncostatin M are significantly decreased after infection.

关 键 词：脑出血 病原菌 神经生长因子 抑瘤素M 炎症因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学]