碳酸氢钠与氟康唑联合治疗口腔真菌感染的临床效果分析  

Clinical efficacy of sodium bicarbonate and fluconazole in the treatment of oral fungal infections

作　　者：蒋俊发 张一兵 石巧云 李文博 张晓明 

机构地区：[1]咸宁市中心医院口腔科,湖北咸宁437100

出　　处：《中华医院感染学杂志》2016年第8期1840-1841,1853,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅重点基金资助项目(SW-2010B-020)

摘　　要：目的探讨联合碳酸氢钠及氟康唑在口腔真菌感染治疗中的应用效果,为临床有效治疗口腔真菌提供临床参考依据。方法选择医院2014年1月-2015年6月收治90例口腔真菌感染患者作为观察对象,并以随机数字表法将患者分为3组,接受生理盐水治疗患者为对照组,接受碳酸氢钠治疗患者为碳酸氢钠组,接受联合碳酸氢钠及氟康唑治疗患者为联合组,各30例;对比3组患者治疗效果,数据采用SPSS 19.0软件进行统计分析。结果患者治疗7d后联合组总有效率为93.33%,明显高于对照组和碳酸氢钠组的30.00%、60.00%,3组间临床治疗总有效率比较差异有统计学意义(P<0.05);3组间药物不良反应发生率比较,差异无统计学意义。结论口腔真菌感染治疗过程中,联合碳酸氢钠及氟康唑可在不增加药物不良反应的同时,有效的提高临床治疗效果,可在临床推广应用。OBJECTIVE To investigate the effect of the joint application of sodium bicarbonate and fluconazole in the treatment of oral fungal infections,in order to provide reference for clinically effective treatment of oral fungal.METHODS Totally 90 patients with oral fungal infections treated in the hospital from Jan.2014-Jun.2015 were included for observation.The patients were randomly divided into three groups,patients received saline treatment were in control group,patients received sodium bicarbonate were in sodium bicarbonate group.Patients received combination of sodium bicarbonate and fluconazole treatment were in joint group.Each group had 30 cases.Clinical effects of 3groups were compared.Data were analyzed with SPSS 19.0.RESULTS After treatment of 7days,total effective rate of joint group was 93.33%,which was significantly higher than control group（30.00%）and sodium bicarbonate group（60.00%）（P〈0.05）.The incidences of adverse reactions among 3groups differences were compared.There was no significance.CONCLUSIONDuring the treatment of oral fungal infection,combined treatment of sodium bicarbonate and fluconazole can effectively improve the clinical effect without increasing adverse drug reactions simultaneously.It is worthy for clinical promotion and application.

关 键 词：碳酸氢钠 氟康唑 口腔 真菌感染 

分 类 号：R781.5[医药卫生—口腔医学]